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Gene Review

Taf1  -  TBP-associated factor 1

Drosophila melanogaster

Synonyms: BG:DS00004.13, CG17603, Dmel\CG17603, EfW1, SR3-5, ...
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Disease relevance of Taf1

  • The recombinant protein expressed in Sf9 cells via a baculovirus vector interacts directly with the 230-kDa subunit of TFIID (p230) [1].

High impact information on Taf1


Biological context of Taf1


Anatomical context of Taf1

  • The cannonball (can) gene of Drosophila encodes a homolog of a TBP-associated factor (dTAF5) protein expressed only in spermatocytes, where it is required for normal transcription of genes required for spermatid differentiation [8].

Associations of Taf1 with chemical compounds


Enzymatic interactions of Taf1

  • Here we report that histone H2B is phosphorylated at evolutionarily conserved Ser33 (H2B-S33) by the carboxyl-terminal kinase domain (CTK) of the Drosophila TFIID subunit TAF1 [10].

Other interactions of Taf1


  1. The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit. Kokubo, T., Gong, D.W., Roeder, R.G., Horikoshi, M., Nakatani, Y. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator. Weinzierl, R.O., Dynlacht, B.D., Tjian, R. Nature (1993) [Pubmed]
  3. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Pham, A.D., Sauer, F. Science (2000) [Pubmed]
  4. TAF250 is required for multiple developmental events in Drosophila. Wassarman, D.A., Aoyagi, N., Pile, L.A., Schlag, E.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. ATM and ATR Pathways Signal Alternative Splicing of Drosophila TAF1 Pre-mRNA in Response to DNA Damage. Katzenberger, R.J., Marengo, M.S., Wassarman, D.A. Mol. Cell. Biol. (2006) [Pubmed]
  6. Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Farmer, G., Colgan, J., Nakatani, Y., Manley, J.L., Prives, C. Mol. Cell. Biol. (1996) [Pubmed]
  7. Identification of highly conserved amino-terminal segments of dTAFII230 and yTAFII145 that are functionally interchangeable for inhibiting TBP-DNA interactions in vitro and in promoting yeast cell growth in vivo. Kotani, T., Miyake, T., Tsukihashi, Y., Hinnebusch, A.G., Nakatani, Y., Kawaichi, M., Kokubo, T. J. Biol. Chem. (1998) [Pubmed]
  8. Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Hiller, M., Chen, X., Pringle, M.J., Suchorolski, M., Sancak, Y., Viswanathan, S., Bolival, B., Lin, T.Y., Marino, S., Fuller, M.T. Development (2004) [Pubmed]
  9. A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Gill, G., Pascal, E., Tseng, Z.H., Tjian, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. TAF1 activates transcription by phosphorylation of serine 33 in histone H2B. Maile, T., Kwoczynski, S., Katzenberger, R.J., Wassarman, D.A., Sauer, F. Science (2004) [Pubmed]
  11. DNA Binding Properties of TAF1 Isoforms with Two AT-hooks. Metcalf, C.E., Wassarman, D.A. J. Biol. Chem. (2006) [Pubmed]
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