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Gene Review:

ANGPT1 - angiopoietin 1

Gallus gallus

Drenkhahn, M. et al., Davey, M.G. et al., Tournaire, R. et al.

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Disease relevance of ANGPT1

OBJECTIVE: To investigate the role of angiopoietin 1 and 2 (ANGPT1/ANGPT2) in angiogenesis of the ectopic endometrium as a crucial step in the development of an endometriotic lesion, we analyzed their expression patterns in an experimental model of endometriosis [1].

High impact information on ANGPT1

We further show that NLLMAAS specifically suppresses both Ang1-induced ERK activity and migration in human umbilical endothelial cells [2].
Gene expression of members of the VEGF and Angiopoietin families of angiogenic growth factors has been linked to haemorrhaging and oedema and we find widespread expression of VEGF-D, rigf and Ang2a in the talpid(3) limb [3].
Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane [1].

References

Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane. Drenkhahn, M., Gescher, D.M., Wolber, E.M., Meyhoefer-Malik, A., Malik, E. Fertil. Steril. (2004) [Pubmed]
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. Tournaire, R., Simon, M.P., le Noble, F., Eichmann, A., England, P., Pouysségur, J. EMBO Rep. (2004) [Pubmed]
Analysis of talpid(3) and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Davey, M.G., James, J., Paton, I.R., Burt, D.W., Tickle, C. Dev. Biol. (2007) [Pubmed]

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