Disease relevance of ANGPT1

• Both hypoxia and VEGF (10 ng/ml) treatment significantly increased angiopoietin-1 (Ang1) mRNA expression [1].

High impact information on ANGPT1

• The activation of anti-apoptotic pathways mediated by Akt and survivin in endothelial cells may contribute to Ang-1 stabilization of vascular structures during angiogenesis, in vivo [2].
• Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [2].
• Angiopoietin-1 (Ang-1) is an endothelium-specific ligand essential for embryonic vascular stabilization, branching morphogenesis, and post-natal angiogenesis, but its contribution to endothelial cell survival has not been completely elucidated [2].
• Here we show that Ang-1 acting via the Tie 2 receptor induces phosphorylation of the survival serine-threonine kinase, Akt (or protein kinase B) [2].
• Recently, the angiopoietin (ANPT)-Tie system has been shown to be required to regulate angiogenesis and blood vessel regression [3].

Biological context of ANGPT1

• Lastly, an RT-PCR analysis of Ang-1 and Ang-2 expression revealed that both molecules are expressed throughout the ovarian cycle [4].
• Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angiogenesis and lymphangiogenesis through the Tek/Tie-2 receptor tyrosine kinase [5].
• Moreover, dominant negative survivin negates the ability of Ang-1 to protect cells from undergoing apoptosis [2].

Anatomical context of ANGPT1

• The role of the angiopoietin/Tie2 system has been studied, but these studies are limited mostly to endothelial cells [1].
• Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes [1].
• Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows [6].
• Involvement of angiopoietin-tie system in bovine follicular development and atresia: messenger RNA expression in theca interna and effect on steroid secretion [3].

References