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Gene Review

ANGPT1  -  angiopoietin 1

Bos taurus

 
 
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Disease relevance of ANGPT1

 

High impact information on ANGPT1

 

Biological context of ANGPT1

  • Lastly, an RT-PCR analysis of Ang-1 and Ang-2 expression revealed that both molecules are expressed throughout the ovarian cycle [4].
  • Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angiogenesis and lymphangiogenesis through the Tek/Tie-2 receptor tyrosine kinase [5].
  • Moreover, dominant negative survivin negates the ability of Ang-1 to protect cells from undergoing apoptosis [2].
 

Anatomical context of ANGPT1

References

  1. Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes. Park, Y.S., Kim, N.H., Jo, I. Microvasc. Res. (2003) [Pubmed]
  2. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. Papapetropoulos, A., Fulton, D., Mahboubi, K., Kalb, R.G., O'Connor, D.S., Li, F., Altieri, D.C., Sessa, W.C. J. Biol. Chem. (2000) [Pubmed]
  3. Involvement of angiopoietin-tie system in bovine follicular development and atresia: messenger RNA expression in theca interna and effect on steroid secretion. Hayashi, K.G., Acosta, T.J., Tetsuka, M., Berisha, B., Matsui, M., Schams, D., Ohtani, M., Miyamoto, A. Biol. Reprod. (2003) [Pubmed]
  4. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Goede, V., Schmidt, T., Kimmina, S., Kozian, D., Augustin, H.G. Lab. Invest. (1998) [Pubmed]
  5. Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. Nguyen, V.P., Chen, S.H., Trinh, J., Kim, H., Coomber, B.L., Dumont, D.J. BMC Cell Biol. (2007) [Pubmed]
  6. Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows. Hayashi, K.G., Berisha, B., Matsui, M., Schams, D., Miyamoto, A. J. Reprod. Dev. (2004) [Pubmed]
 
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