The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ANGPT1  -  angiopoietin 1

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ANGPT1


High impact information on ANGPT1


Biological context of ANGPT1

  • Lastly, an RT-PCR analysis of Ang-1 and Ang-2 expression revealed that both molecules are expressed throughout the ovarian cycle [4].
  • Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angiogenesis and lymphangiogenesis through the Tek/Tie-2 receptor tyrosine kinase [5].
  • Moreover, dominant negative survivin negates the ability of Ang-1 to protect cells from undergoing apoptosis [2].

Anatomical context of ANGPT1


  1. Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes. Park, Y.S., Kim, N.H., Jo, I. Microvasc. Res. (2003) [Pubmed]
  2. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. Papapetropoulos, A., Fulton, D., Mahboubi, K., Kalb, R.G., O'Connor, D.S., Li, F., Altieri, D.C., Sessa, W.C. J. Biol. Chem. (2000) [Pubmed]
  3. Involvement of angiopoietin-tie system in bovine follicular development and atresia: messenger RNA expression in theca interna and effect on steroid secretion. Hayashi, K.G., Acosta, T.J., Tetsuka, M., Berisha, B., Matsui, M., Schams, D., Ohtani, M., Miyamoto, A. Biol. Reprod. (2003) [Pubmed]
  4. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Goede, V., Schmidt, T., Kimmina, S., Kozian, D., Augustin, H.G. Lab. Invest. (1998) [Pubmed]
  5. Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. Nguyen, V.P., Chen, S.H., Trinh, J., Kim, H., Coomber, B.L., Dumont, D.J. BMC Cell Biol. (2007) [Pubmed]
  6. Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows. Hayashi, K.G., Berisha, B., Matsui, M., Schams, D., Miyamoto, A. J. Reprod. Dev. (2004) [Pubmed]
WikiGenes - Universities