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Gene Review

Angpt1  -  angiopoietin 1

Rattus norvegicus

Synonyms: ANG-1, Agpt, Agpt1, Ang-1, Angiopoietin-1
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Disease relevance of Angpt1


High impact information on Angpt1


Chemical compound and disease context of Angpt1


Biological context of Angpt1


Anatomical context of Angpt1


Associations of Angpt1 with chemical compounds

  • Gene and protein expression of VEGF, Ang-1, and Ang-2 were increased by angiotensin II infusion [13].
  • Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model [15].
  • Recent studies have implicated the Tie2 tyrosine-kinase receptor and its main ligands--angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2)--as crucial regulators of mural cell recruitment during angiogenesis [12].
  • Ang-1 gene transfer attenuated the LPS-induced increases in ppET-1 RNA and lavage ET-1 protein by 34% and 33%, respectively (P < 0.05) [16].
  • Neutralizing Ang1 antibody attenuates DETA-NONOate-induced capillary tube formation [17].

Physical interactions of Angpt1


Regulatory relationships of Angpt1

  • In addition, immunohistochemical detection of fibronectin was used to detect BBB breakdown at the lesion site and dual labeling was used to determine whether the vessels demonstrating BBB breakdown expressed endothelial Ang-1 or Ang-2 [2].
  • Ang II also upregulated vascular endothelial growth factor (VEGF) expression in an HB-EGF/EGFR-dependent manner [11].
  • PCT-CM-induced occludin up-regulation was significantly inhibited by an angiopoietin-1-neutralizing antibody, whereas the up-regulation by AST-CM was not [18].
  • We conclude that Ang-1 promotes neurite outgrowth from DRG cells positive for Tie-2 receptor [19].
  • In the 1 h hypoxia group, there was significant induction of Ang-2 expression (31.3% compared to its baseline control) in contrast to relatively mild Ang-1 expression (23.8% compared to its baseline control) [20].

Other interactions of Angpt1


Analytical, diagnostic and therapeutic context of Angpt1


  1. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Sandhu, R., Teichert-Kuliszewska, K., Nag, S., Proteau, G., Robb, M.J., Campbell, A.I., Kuliszewski, M.A., Kutryk, M.J., Stewart, D.J. Cardiovasc. Res. (2004) [Pubmed]
  2. Altered expression of angiopoietins during blood-brain barrier breakdown and angiogenesis. Nourhaghighi, N., Teichert-Kuliszewska, K., Davis, J., Stewart, D.J., Nag, S. Lab. Invest. (2003) [Pubmed]
  3. Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors. Takazawa, Y., Maeshima, Y., Kitayama, H., Yamamoto, Y., Kawachi, H., Shimizu, F., Matsui, H., Sugiyama, H., Yamasaki, Y., Makino, H. Kidney Int. (2005) [Pubmed]
  4. Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats. Ohashi, H., Takagi, H., Koyama, S., Oh, H., Watanabe, D., Antonetti, D.A., Matsubara, T., Nagai, K., Arai, H., Kita, T., Honda, Y. Mol. Vis. (2004) [Pubmed]
  5. Senescent impairment in synergistic cytokine pathways that provide rapid cardioprotection in the rat heart. Xaymardan, M., Zheng, J., Duignan, I., Chin, A., Holm, J.M., Ballard, V.L., Edelberg, J.M. J. Exp. Med. (2004) [Pubmed]
  6. Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin. Sarlos, S., Rizkalla, B., Moravski, C.J., Cao, Z., Cooper, M.E., Wilkinson-Berka, J.L. Am. J. Pathol. (2003) [Pubmed]
  7. Suppression of diabetic retinopathy with angiopoietin-1. Joussen, A.M., Poulaki, V., Tsujikawa, A., Qin, W., Qaum, T., Xu, Q., Moromizato, Y., Bursell, S.E., Wiegand, S.J., Rudge, J., Ioffe, E., Yancopoulos, G.D., Adamis, A.P. Am. J. Pathol. (2002) [Pubmed]
  8. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. Beck, H., Acker, T., Wiessner, C., Allegrini, P.R., Plate, K.H. Am. J. Pathol. (2000) [Pubmed]
  9. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen, C.Y., Ito, M., Chen, L.D., Matsuu, M., Shichijo, K., Nakayama, T., Nakashima, M., Xu, Z.M., Ohtsuru, A., Hsu, C.T., Sekine, I. J. Gastroenterol. (2003) [Pubmed]
  10. Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Hall, E., Brookes, Z.L. Regul. Pept. (2005) [Pubmed]
  11. Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Fujiyama, S., Matsubara, H., Nozawa, Y., Maruyama, K., Mori, Y., Tsutsumi, Y., Masaki, H., Uchiyama, Y., Koyama, Y., Nose, A., Iba, O., Tateishi, E., Ogata, N., Jyo, N., Higashiyama, S., Iwasaka, T. Circ. Res. (2001) [Pubmed]
  12. Rat aorta-derived mural precursor cells express the Tie2 receptor and respond directly to stimulation by angiopoietins. Iurlaro, M., Scatena, M., Zhu, W.H., Fogel, E., Wieting, S.L., Nicosia, R.F. J. Cell. Sci. (2003) [Pubmed]
  13. Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors. Rizkalla, B., Forbes, J.M., Cooper, M.E., Cao, Z. J. Am. Soc. Nephrol. (2003) [Pubmed]
  14. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu, K.G., Liang, Y.J., Chang, H., Wang, B.W., Leu, J.G., Kuan, P. J. Biomed. Sci. (2004) [Pubmed]
  15. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, M.M., Munzenmaier, D.H., Hurn, P.D. Stroke (2005) [Pubmed]
  16. Regulation of endothelin-1 by angiopoietin-1: implications for inflammation. McCarter, S.D., Lai, P.F., Suen, R.S., Stewart, D.J. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  17. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Zacharek, A., Chen, J., Zhang, C., Cui, X., Roberts, C., Jiang, H., Teng, H., Chopp, M. Neurosci. Lett. (2006) [Pubmed]
  18. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., Terasaki, T. J. Neurochem. (2004) [Pubmed]
  19. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka, J., Figiel, M., Engele, J., Hilbig, H., Majewski, M., Spanel-Borowski, K. Cell Tissue Res. (2005) [Pubmed]
  20. Early effects of hypoxia/reoxygenation on VEGF, ang-1, ang-2 and their receptors in the rat myocardium: implications for myocardial angiogenesis. Ray, P.S., Estrada-Hernandez, T., Sasaki, H., Zhu, L., Maulik, N. Mol. Cell. Biochem. (2000) [Pubmed]
  21. Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Rizkalla, B., Forbes, J.M., Cao, Z., Boner, G., Cooper, M.E. J. Hypertens. (2005) [Pubmed]
  22. Superior cervical ganglionectomy induces changes in growth factor expression in the rat retina. Wiley, L.A., Berkowitz, B.A., Steinle, J.J. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  23. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu, K.G., Chang, C.C., Wang, B.W., Kuan, P., Chang, H. Clin. Sci. (2003) [Pubmed]
  24. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Chu, D., Sullivan, C.C., Du, L., Cho, A.J., Kido, M., Wolf, P.L., Weitzman, M.D., Jamieson, S.W., Thistlethwaite, P.A. Ann. Thorac. Surg. (2004) [Pubmed]
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