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Gene Review

Angpt1  -  angiopoietin 1

Mus musculus

Synonyms: 1110046O21Rik, ANG-1, Agpt, Ang-1, Ang1, ...
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Disease relevance of Angpt1


High impact information on Angpt1


Chemical compound and disease context of Angpt1

  • Recombinant human Ang-1 antisense eukaryotic expression vector was constructed by directional cloning, and transfected by lipofectin method into human gastric cancer line SGC7901 with high Ang-1 expression level [11].

Biological context of Angpt1


Anatomical context of Angpt1


Associations of Angpt1 with chemical compounds

  • Here, we demonstrate that angiopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains-2 (Tie2) signaling contributes to the assembly and remodeling of BM neovessels after myelosuppression [1].
  • Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis [15].
  • Thirty minutes of pretreatment with the NADPH oxidase inhibitors diphenylene iodinium (DPI, 10 muM) and apocynin (200 muM) suppressed Ang-1-stimulated ROS [16].
  • After intraperitoneal glucose challenge, COMP-Ang1 significantly lowered plasma glucose levels [5].
  • Examination of the uteri revealed Ang-2 mRNA and protein expression in the oestrogen-dominated cycling phase and the progesterone-dominated mated phase, whereas Ang-1 expression was restricted to the mated phase [17].

Physical interactions of Angpt1


Regulatory relationships of Angpt1


Other interactions of Angpt1


Analytical, diagnostic and therapeutic context of Angpt1


  1. Tie2 activation contributes to hemangiogenic regeneration after myelosuppression. Kopp, H.G., Avecilla, S.T., Hooper, A.T., Shmelkov, S.V., Ramos, C.A., Zhang, F., Rafii, S. Blood (2005) [Pubmed]
  2. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. Yu, Q., Stamenkovic, I. Am. J. Pathol. (2001) [Pubmed]
  3. Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis. Yuan, H.T., Tipping, P.G., Li, X.Z., Long, D.A., Woolf, A.S. Kidney Int. (2002) [Pubmed]
  4. Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularization. Das, A., Fanslow, W., Cerretti, D., Warren, E., Talarico, N., McGuire, P. Lab. Invest. (2003) [Pubmed]
  5. Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Lee, S., Kim, W., Moon, S.O., Sung, M.J., Kim, D.H., Kang, K.P., Jang, K.Y., Lee, S.Y., Park, B.H., Koh, G.Y., Park, S.K. Nephrol. Dial. Transplant. (2007) [Pubmed]
  6. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G.Y., Suda, T. Cell (2004) [Pubmed]
  7. Mekk3 is essential for early embryonic cardiovascular development. Yang, J., Boerm, M., McCarty, M., Bucana, C., Fidler, I.J., Zhuang, Y., Su, B. Nat. Genet. (2000) [Pubmed]
  8. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T.N., Yancopoulos, G.D., McDonald, D.M. Science (1999) [Pubmed]
  9. Increased vascularization in mice overexpressing angiopoietin-1. Suri, C., McClain, J., Thurston, G., McDonald, D.M., Zhou, H., Oldmixon, E.H., Sato, T.N., Yancopoulos, G.D. Science (1998) [Pubmed]
  10. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Pereira, F.A., Qiu, Y., Zhou, G., Tsai, M.J., Tsai, S.Y. Genes Dev. (1999) [Pubmed]
  11. Antisense angiopoietin-1 inhibits tumorigenesis and angiogenesis of gastric cancer. Wang, J., Wu, K.C., Zhang, D.X., Fan, D.M. World J. Gastroenterol. (2006) [Pubmed]
  12. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Morisada, T., Oike, Y., Yamada, Y., Urano, T., Akao, M., Kubota, Y., Maekawa, H., Kimura, Y., Ohmura, M., Miyamoto, T., Nozawa, S., Koh, G.Y., Alitalo, K., Suda, T. Blood (2005) [Pubmed]
  13. Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Kämpfer, H., Pfeilschifter, J., Frank, S. Lab. Invest. (2001) [Pubmed]
  14. Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Fan, F., Stoeltzing, O., Liu, W., McCarty, M.F., Jung, Y.D., Reinmuth, N., Ellis, L.M. Cancer Res. (2004) [Pubmed]
  15. Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis. Kim, Y.M., Kim, K.E., Koh, G.Y., Ho, Y.S., Lee, K.J. Cancer Res. (2006) [Pubmed]
  16. Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. Chen, J.X., Zeng, H., Lawrence, M.L., Blackwell, T.S., Meyrick, B. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  17. Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation. Hess, A.P., Hirchenhain, J., Schanz, A., Talbi, S., Hamilton, A.E., Giudice, L.C., Krüssel, J.S. Reprod. Fertil. Dev. (2006) [Pubmed]
  18. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Lehmann, W., Edgar, C.M., Wang, K., Cho, T.J., Barnes, G.L., Kakar, S., Graves, D.T., Rueger, J.M., Gerstenfeld, L.C., Einhorn, T.A. Bone (2005) [Pubmed]
  19. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Stoeltzing, O., Ahmad, S.A., Liu, W., McCarty, M.F., Wey, J.S., Parikh, A.A., Fan, F., Reinmuth, N., Kawaguchi, M., Bucana, C.D., Ellis, L.M. Cancer Res. (2003) [Pubmed]
  20. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. Saaristo, A., Veikkola, T., Enholm, B., Hytönen, M., Arola, J., Pajusola, K., Turunen, P., Jeltsch, M., Karkkainen, M.J., Kerjaschki, D., Bueler, H., Ylä-Herttuala, S., Alitalo, K. FASEB J. (2002) [Pubmed]
  21. Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. Yuan, H.T., Suri, C., Yancopoulos, G.D., Woolf, A.S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  22. Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair. Féraud, O., Mallet, C., Vilgrain, I. Endocrinology (2003) [Pubmed]
  23. Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis. Larcher, F., Franco, M., Bolontrade, M., Rodriguez-Puebla, M., Casanova, L., Navarro, M., Yancopoulos, G., Jorcano, J.L., Conti, C.J. Mol. Carcinog. (2003) [Pubmed]
  24. Angiopoietin-1 and VEGF in vascular development and angiogenesis in hypoplastic lungs. Chinoy, M.R., Graybill, M.M., Miller, S.A., Lang, C.M., Kauffman, G.L. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  25. Vascular development in the mouse embryonic pancreas and lung. Colen, K.L., Crisera, C.A., Rose, M.I., Connelly, P.R., Longaker, M.T., Gittes, G.K. J. Pediatr. Surg. (1999) [Pubmed]
  26. Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma. Torimura, T., Ueno, T., Kin, M., Taniguchi, E., Nakamura, T., Inoue, K., Sakata, R., Hashimoto, O., Sakamoto, M., Ohira, H., Kumashiro, R., Sata, M., Yano, H., Kojiro, M., Veitonmaki, N., Cao, Y. Gastroenterology (2006) [Pubmed]
  27. Inhibition of angiopoietin-1 expression in tumor cells by an antisense RNA approach inhibited xenograft tumor growth in immunodeficient mice. Shim, W.S., Teh, M., Mack, P.O., Ge, R. Int. J. Cancer (2001) [Pubmed]
  28. Neutrophils promote experimental choroidal neovascularization. Zhou, J., Pham, L., Zhang, N., He, S., Gamulescu, M.A., Spee, C., Ryan, S.J., Hinton, D.R. Mol. Vis. (2005) [Pubmed]
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