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Gene Review

VEGFA  -  vascular endothelial growth factor A

Gallus gallus

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Disease relevance of VEGFA


High impact information on VEGFA


Chemical compound and disease context of VEGFA


Biological context of VEGFA


Anatomical context of VEGFA


Associations of VEGFA with chemical compounds

  • In a differential display screening for genes regulated by retinoic acid in the developing chick limb bud, we have isolated a novel gene, termed rigf, retinoic-acid induced growth factor, that encodes a protein belonging to the vascular endothelial growth factor (VEGF) family [20].
  • We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization [21].
  • CONCLUSIONS: The findings suggest that the induction of angiogenesis and VEGF expression by ethanol represents an important mechanism of cancer progression associated with alcoholic beverage consumption [13].
  • PGE2 dose-dependently inhibited the expression of the differentiation-related genes, colX, VEGF, MMP-13, and alkaline phosphatase gene, and enzyme activity with significant effects at concentrations as low as 10(-10) M [22].
  • Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression [12].

Regulatory relationships of VEGFA

  • These observations are in accordance with the proposal that Ang-2 induces angiogenesis in the presence of VEGF and vascular regression in its absence [23].

Other interactions of VEGFA


Analytical, diagnostic and therapeutic context of VEGFA


  1. VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation. Hashimoto, T., Zhang, X.M., Chen, B.Y., Yang, X.J. Development (2006) [Pubmed]
  2. A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane. Van Lieshout, T., Stanisz, J., Espiritu, V., Richardson, M., Singh, G. Int. J. Oncol. (2003) [Pubmed]
  3. Endothelial effects of 3-hydroxyglutaric acid: implications for glutaric aciduria type I. Mühlhausen, C., Ott, N., Chalajour, F., Tilki, D., Freudenberg, F., Shahhossini, M., Thiem, J., Ullrich, K., Braulke, T., Ergün, S. Pediatr. Res. (2006) [Pubmed]
  4. Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion. Wu, X.H., Zhou, H.J., Lee, J. Anticancer Drugs (2006) [Pubmed]
  5. Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Nguyen, Q.D., Rodrigues, S., Rodrigue, C.M., Rivat, C., Grijelmo, C., Bruyneel, E., Emami, S., Attoub, S., Gespach, C. Mol. Cancer Ther. (2006) [Pubmed]
  6. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., Naito, M., Nakao, K., Nishikawa, S. Nature (2000) [Pubmed]
  7. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Eliceiri, B.P., Paul, R., Schwartzberg, P.L., Hood, J.D., Leng, J., Cheresh, D.A. Mol. Cell (1999) [Pubmed]
  8. Chemotactic cell movement during Dictyostelium development and gastrulation. Dormann, D., Weijer, C.J. Curr. Opin. Genet. Dev. (2006) [Pubmed]
  9. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. Veikkola, T., Jussila, L., Makinen, T., Karpanen, T., Jeltsch, M., Petrova, T.V., Kubo, H., Thurston, G., McDonald, D.M., Achen, M.G., Stacker, S.A., Alitalo, K. EMBO J. (2001) [Pubmed]
  10. Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Ebrahem, Q., Renganathan, K., Sears, J., Vasanji, A., Gu, X., Lu, L., Salomon, R.G., Crabb, J.W., Anand-Apte, B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation. Yang, S.H., Lin, J.K., Huang, C.J., Chen, W.S., Li, S.Y., Chiu, J.H. J. Surg. Res. (2005) [Pubmed]
  12. Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression. Fang, J., Zhou, Q., Liu, L.Z., Xia, C., Hu, X., Shi, X., Jiang, B.H. Carcinogenesis (2007) [Pubmed]
  13. Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos. Gu, J.W., Bailey, A.P., Sartin, A., Makey, I., Brady, A.L. Cancer (2005) [Pubmed]
  14. 2,3,7,8-tetrachlorodibenzo-p-dioxin reduces myocardial hypoxia and vascular endothelial growth factor expression during chick embryo development. Ivnitski-Steele, I.D., Sanchez, A., Walker, M.K. Birth defects research. Part A, Clinical and molecular teratology. (2004) [Pubmed]
  15. Analysis of talpid(3) and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Davey, M.G., James, J., Paton, I.R., Burt, D.W., Tickle, C. Dev. Biol. (2007) [Pubmed]
  16. An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. Lee, H.J., Lee, E.O., Rhee, Y.H., Ahn, K.S., Li, G.X., Jiang, C., L??, J., Kim, S.H. Carcinogenesis (2006) [Pubmed]
  17. Expression of the chick vascular endothelial growth factor D gene during limb development. Trelles, R.D., León, J.R., Kawakami, Y., Simoes, S., Belmonte, J.C. Mech. Dev. (2002) [Pubmed]
  18. Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius. Ribatti, D., De Falco, G., Vacca, A., Nico, B., Errede, M., Roccaro, A.M., Roncali, L., Dammacco, F. Int. J. Mol. Med. (2001) [Pubmed]
  19. VEGF coordinates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis. Hagedorn, M., Balke, M., Schmidt, A., Bloch, W., Kurz, H., Javerzat, S., Rousseau, B., Wilting, J., Bikfalvi, A. Dev. Dyn. (2004) [Pubmed]
  20. Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. Tamura, K., Amano, T., Satoh, T., Saito, D., Yonei-Tamura, S., Yajima, H. Mech. Dev. (2003) [Pubmed]
  21. Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane. Cruz, A., Parnot, C., Ribatti, D., Corvol, P., Gasc, J.M. J. Vasc. Res. (2001) [Pubmed]
  22. PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Li, T.F., Zuscik, M.J., Ionescu, A.M., Zhang, X., Rosier, R.N., Schwarz, E.M., Drissi, H., O'Keefe, R.J. Exp. Cell Res. (2004) [Pubmed]
  23. Characterization of a novel form of angiopoietin-2 (Ang-2B) and expression of VEGF and angiopoietin-2 during chicken testicular development and regression. Mezquita, J., Mezquita, B., Pau, M., Mezquita, C. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  24. Synthetic oligosaccharide stimulates and stabilizes angiogenesis: structure-function relationships and potential mechanisms. Mousa, S.A., Feng, X., Xie, J., Du, Y., Hua, Y., He, H., O'Connor, L., Linhardt, R.J. J. Cardiovasc. Pharmacol. (2006) [Pubmed]
  25. In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane. Ribatti, D., Cruz, A., Nico, B., Favier, J., Vacca, A., Corsi, P., Roncali, L., Dammacco, F. Cytokine (2002) [Pubmed]
  26. Supercritical carbon dioxide generated vascular endothelial growth factor encapsulated poly(dl-lactic acid) scaffolds induce angiogenesis in vitro. Kanczler, J.M., Barry, J., Ginty, P., Howdle, S.M., Shakesheff, K.M., Oreffo, R.O. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  27. Molecular cloning of a family of protein kinase genes expressed in the avian embryo. Marcelle, C., Eichmann, A. Oncogene (1992) [Pubmed]
  28. Cartilage canals in the chicken embryo: ultrastructure and function. Blumer, M.J., Fritsch, H., Pfaller, K., Brenner, E. Anat. Embryol. (2004) [Pubmed]
  29. Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis. Ribatti, D., Nico, B., Morbidelli, L., Donnini, S., Ziche, M., Vacca, A., Roncali, L., Presta, M. J. Vasc. Res. (2001) [Pubmed]
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