High impact information on MYO6

• Myosin VI is involved in a wide variety of intracellular processes such as endocytosis, secretion and cell migration [1].
• Myosin-VI exists in both the microvillus and terminal web although the terminal web is the predominant site of concentration [2].
• In the undifferentiated enterocytes of the intestinal crypts, myosin-VI is expressed but not yet localized to the brush border, in contrast to myosin-V, which does demonstrate an apical distribution in these cells [2].
• Moreover, a population of supporting cells expressed myosin VI at 78 hours after gentamicin treatment and myosin VIIa at 90 hours [3].
• Some of these mitotically produced cells began to differentiate into hair cells at 108 hours after gentamicin (36 hours after bromodeoxyuridine (BrdU) administration), as demonstrated by the colabeling of myosin VI and BrdU [3].

Anatomical context of MYO6

• Additionally, we identified markers of the trans-Golgi network, components of the exocyst complex, and several motor proteins including myosin 1C, non-muscle myosins IIA and IIB, myosin VI, and myosin IXB [4].

Analytical, diagnostic and therapeutic context of MYO6

• Using an optical tweezers-based force transducer we found that expressed myosin VI is nonprocessive and produces a large working stroke of 18 nm [1].

References