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Gene Review

RDX  -  radixin

Gallus gallus

 
 
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High impact information on RDX

  • We have assayed the domains of the ERM protein radixin for binding activities in vitro [1].
  • Affinity columns bearing the amino-terminal domain of radixin selectively bound a small subset of the proteins of the chicken erythrocyte cytoskeleton [1].
  • Both ezrin and radixin localize to the position of the marginal band [2].
  • Withdrawal of nerve growth factor (NGF) induces rapid collapse of the growth cones; concomitantly, radixin staining in these growth cones are greatly diminished [3].
  • These results suggest that CLIC5 associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core [4].
 

Biological context of RDX

 

Anatomical context of RDX

  • The results demonstrate that radixin is the major ERM protein associated with the cytoskeleton [2].
  • We show that the radixin staining of the growth cones is also asymmetrically localized toward the leading edges in the new direction of growth [3].
  • The ERM protein--ezrin, radixin, moesin--localize to a variety of cortical structures, where they may participate in connecting the cytoskeleton to components of the plasma membrane [3].
  • Refined immunolocalization in rat and chicken vestibular hair cells showed that CLIC5 is limited to the basal region of the hair bundle, similar to the known location of radixin [4].
  • By mass spectrometry and immunoblotting, CLIC5 was shown to be expressed at high levels in stereocilia of the chicken utricle, in an approximate 1:1 molar ratio with radixin [4].

References

  1. Interdomain interactions of radixin in vitro. Magendantz, M., Henry, M.D., Lander, A., Solomon, F. J. Biol. Chem. (1995) [Pubmed]
  2. Analysis of a cortical cytoskeletal structure: a role for ezrin-radixin-moesin (ERM proteins) in the marginal band of chicken erythrocytes. Winckler, B., González Agosti, C., Magendantz, M., Solomon, F. J. Cell. Sci. (1994) [Pubmed]
  3. Response of radixin to perturbations of growth cone morphology and motility in chick sympathetic neurons in vitro. Gonzalez-Agosti, C., Solomon, F. Cell Motil. Cytoskeleton (1996) [Pubmed]
  4. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. Gagnon, L.H., Longo-Guess, C.M., Berryman, M., Shin, J.B., Saylor, K.W., Yu, H., Gillespie, P.G., Johnson, K.R. J. Neurosci. (2006) [Pubmed]
  5. Cloning and expression profile of chicken radixin. Li, W., Crouch, D.H. Biochim. Biophys. Acta (2000) [Pubmed]
 
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