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Gene Review

Rdx  -  radixin

Rattus norvegicus

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Disease relevance of Rdx


High impact information on Rdx

  • The increase in these cytoskeletal proteins appears to be regulated primarily (radixin) or partially (moesin) posttranscriptionally [1].
  • Moesin and radixin mRNA and protein are constitutively expressed in all cell types of normal rat glomeruli, except podocytes [1].
  • The data suggest that PDGF mediated upregulation of the cytoskeletal proteins, moesin and radixin, is important for cell migration and other changes that accompany the coordinated restoration of glomerular architecture after injury [1].
  • Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons [3].
  • Taken collectively, our data suggest that by regulating key aspects of growth cone development and maintenance, radixin and moesin modulate neurite formation and the development of neuronal polarity [3].

Biological context of Rdx

  • Furthermore, the expression level of membranous RhoA and phosphorylation of the target proteins of Rho-kinase, the ERM (ezrin, radixin, moesin) family members, was significantly greater in L-NAME-treated rats than in control rats [4].
  • Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis [2].
  • Radixin appeared to accumulate rapidly at the cleavage furrow at the onset of furrowing, continued to be concentrated at the furrow during anaphase and telophase, and was finally enriched at the midbody [2].

Anatomical context of Rdx


Other interactions of Rdx

  • Specific knockdown of Mrp2 (approximately 50% decrease in expression) resulted in an approximately 45% decrease in the biliary excretion index of carboxydichlorofluorescein (CDF) (9.3% versus 16.5%), but did not affect Mrp3 or radixin expression [9].


  1. The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis. Hugo, C., Hugo, C., Pichler, R., Gordon, K., Schmidt, R., Amieva, M., Couser, W.G., Furthmayr, H., Johnson, R.J. J. Clin. Invest. (1996) [Pubmed]
  2. Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis. Sato, N., Yonemura, S., Obinata, T., Tsukita, S., Tsukita, S. J. Cell Biol. (1991) [Pubmed]
  3. Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons. Paglini, G., Kunda, P., Quiroga, S., Kosik, K., Cáceres, A. J. Cell Biol. (1998) [Pubmed]
  4. Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition. Ito, K., Hirooka, Y., Kishi, T., Kimura, Y., Kaibuchi, K., Shimokawa, H., Takeshita, A. Hypertension (2004) [Pubmed]
  5. Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium. Bonilha, V.L., Finnemann, S.C., Rodriguez-Boulan, E. J. Cell Biol. (1999) [Pubmed]
  6. Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes. Melendez-Vasquez, C.V., Rios, J.C., Zanazzi, G., Lambert, S., Bretscher, A., Salzer, J.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in glomerulogenesis, in the adult kidney and in glomerular injury. Hugo, C., Nangaku, M., Shankland, S.J., Pichler, R., Gordon, K., Amieva, M.R., Couser, W.G., Furthmayr, H., Johnson, R.J. Kidney Int. (1998) [Pubmed]
  8. A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. Tsukita, S., Hieda, Y., Tsukita, S. J. Cell Biol. (1989) [Pubmed]
  9. Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes. Tian, X., Zamek-Gliszczynski, M.J., Zhang, P., Brouwer, K.L. Mol. Pharmacol. (2004) [Pubmed]
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