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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TEAD4  -  TEA domain family member 4

Gallus gallus

Synonyms: RTEF-1, TEF-1, TEF-3
 
 
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Disease relevance of TEAD4

 

High impact information on TEAD4

  • An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo [1].
  • MCBF also bound to the M-CAT motif in the distal promoter region of the skeletal alpha-actin gene, suggesting that it may play a role in the regulation of this and perhaps other muscle genes that contain M-CAT motifs [3].
  • The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues [4].
  • Here, we have examined the tissue distribution of TEF-1-related proteins and of M-CAT binding activity by Western analysis and mobility shift polyacrylamide gel electrophoresis [4].
  • RTEF-1 mRNA is muscle-enriched, consistent with a role for RTEF-1 in the regulation of muscle-specific gene expression [4].
 

Biological context of TEAD4

  • Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1 [5].
  • Minimal promoter constructs were evaluated by direct injection into the ALD, which demonstrated that both serum response element 1 (SRE1) and the transcriptional enhancer factor 1 (TEF-1) elements were sufficient for increased expression during stretch overload [2].
 

Anatomical context of TEAD4

  • We show that TEF-1 mRNA is considerably enriched in cardiac and skeletal muscle, consistent with a proposed role in muscle gene transcription [6].
 

Analytical, diagnostic and therapeutic context of TEAD4

References

  1. An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo. Molkentin, J.D., Markham, B.E. Mol. Cell. Biol. (1994) [Pubmed]
  2. SRF and TEF-1 control of chicken skeletal alpha-actin gene during slow-muscle hypertrophy. Carson, J.A., Schwartz, R.J., Booth, F.W. Am. J. Physiol. (1996) [Pubmed]
  3. M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription. Mar, J.H., Ordahl, C.P. Mol. Cell. Biol. (1990) [Pubmed]
  4. The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues. Farrance, I.K., Ordahl, C.P. J. Biol. Chem. (1996) [Pubmed]
  5. Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. MacLellan, W.R., Lee, T.C., Schwartz, R.J., Schneider, M.D. J. Biol. Chem. (1994) [Pubmed]
  6. Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. Stewart, A.F., Larkin, S.B., Farrance, I.K., Mar, J.H., Hall, D.E., Ordahl, C.P. J. Biol. Chem. (1994) [Pubmed]
  7. Regulation of troponin T gene expression in chicken fast skeletal muscle: involvement of an M-CAT-like element distinct from the standard M-CAT. Watanabe, T., Takemasa, T., Yonemura, I., Hirabayashi, T. J. Biochem. (1997) [Pubmed]
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