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Gene Review

DCTN2  -  dynactin 2 (p50)

Gallus gallus

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Disease relevance of P50

  • A convincing correlation between body weight and P50 could not be established, even when including data from other authors [1].

High impact information on P50

  • At 100-fold excess over heme, Ap4A increases the P50 of stripped Hb A in 0.05 M HEPES buffer at pH 7.25, 20 degrees C, from 0.85 to 6.03 mm Hg [2].
  • The ability of the chicken erythrocyte to accumulate 2,3-bisphosphoglycerate (2,3-P2-glycerate) and its effect upon the oxygen affinity (P50) of the cell suspensions have been determined [3].
  • The delta P50/mumol increase in 2,3-P2-glycerate in the red cells of the 20-day chick embryo after 4 h incubation is 1.5 Torr; conversely, the delta P50/mumol decrease in 2,3-P2-glycerate in the red cells of the 17-day embryo after 6 h incubation in the presence of sodium bisulfite is 2.8 Torr [3].
  • The curves determined by the two methods of data analysis corresponded closely, the P50 values (x +/- SD) being 36.2 +/- 2.5, 34.3 +/- 3.1 Torr, respectively [4].

Associations of P50 with chemical compounds

  • Further, erythrocytes from 9- and 11-week, and 7-, 14-, 24-, and 28-month-old chickens when incubated similarly with inosine and pyruvate accumulated 2,3-P2-glycerate with corresponding increases in P50 of the cell suspensions [3].


  1. A comparative study of the respiratory properties of bird blood. Baumann, F.H., Baumann, R. Respiration physiology. (1977) [Pubmed]
  2. Alteration of hemoglobin function by diadenosine 5',5'''-P1,P4-tetraphosphate and other alarmones. Bonaventura, C., Cashon, R., Colacino, J.M., Hilderman, R.H. J. Biol. Chem. (1992) [Pubmed]
  3. Studies on avian erythrocyte metabolism. XVI. Accumulation of 2,3-bisphosphoglycerate with shifts in oxygen affinity of chicken erythrocytes. Isaacks, R.E., Lai, L.L., Goldman, P.H., Kim, C.Y. Arch. Biochem. Biophys. (1987) [Pubmed]
  4. Chicken oxygen dissociation curve by dynamic tonometry. Boyd, R.L., Clark, C.H., McDaniel, G.R. Poult. Sci. (1980) [Pubmed]
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