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Gene Review:

Dctn2 - dynactin 2

Mus musculus

Synonyms: 2310042E05Rik, 50 kDa dynein-associated polypeptide, C130077D06Rik, C87049, DCTN-50, ...

Moore, C.A. et al., Uetake, Y. et al., Vig, B.K.

Vig,

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High impact information on Dctn2

These results suggest that Cep135 and p50 play an important role in assembly and maintenance of functional microtubule-organizing centers [1].
One clone encoded dynamitin, a p50 dynactin subunit, which localized at the centrosome and has been shown to be involved in anchoring microtubules to centrosomes [1].
Antibodies against one component of dynein, namely IC, and two components of dynactin, namely p50 and p150, were studied for their activity against the centromeres of three mammalian species, human, mouse and Indian muntjac [2].

Biological context of Dctn2

In addition, the microtubule-associated proteins CLASP2 (a CLIP associating protein) and dynactin-p50 are found on kinetochores and a subset of microtubule-organising centres [3].

References

Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Uetake, Y., Terada, Y., Matuliene, J., Kuriyama, R. Cell Motil. Cytoskeleton (2004) [Pubmed]
Recognition of mammalian centromeres by anti-dynein and anti-dynactin components. Vig, B.K. Mutagenesis (1998) [Pubmed]
PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. Moore, C.A., Zernicka-Goetz, M. Reproduction (2005) [Pubmed]

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DCTN2_ANOGA	Anopheles gambiae str. PEST
DCTN2	Bos taurus
dnc-2	Caenorhabditis elegans
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Dmn	Drosophila melanogaster
DCTN2	Gallus gallus
DCTN2	Homo sapiens
DCTN2	Macaca mulatta
DCTN2	Pan troglodytes
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dctn2	Xenopus (Silurana) tropicalis

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