Psychiatry related information on Dmn

• RESULTS: We analyzed dynein function in the oocyte by disrupting motor activity through temporally restricted expression of the dynactin subunit, dynamitin [1].

High impact information on Dmn

• Mutant dynactin in motor neuron disease [2].
• Mutation analysis of a gene in this interval that encodes the largest subunit of the axonal transport protein dynactin showed a single base-pair change resulting in an amino-acid substitution that is predicted to distort the folding of dynactin's microtubule-binding domain [2].
• We describe the dynamics of kinetochore dynein-dynactin in living Drosophila embryos and examine the effect of mutant dynein on the metaphase checkpoint [3].
• A functional conjugate of dynamitin with green fluorescent protein accumulates rapidly at prometaphase kinetochores, and subsequently migrates off kinetochores towards the poles during late prometaphase and metaphase [3].
• Nocodazole treatment of cells results in an extensive BICD2-dynactin-dynein co-localization [4].

Biological context of Dmn

• Rough Deal (Rod) and Zw10 are components of a complex required for the metazoan metaphase checkpoint and for recruitment of dynein/dynactin to the kinetochore [5].
• Together, these findings suggest that axoneme assembly and spermatid growth involve independent mechanisms in Drosophila and DDLC1 interacts with the Dynein-Dynactin complex at the distal ends of spermatids to maintain the spectrin cytoskeleton assembly and cell growth [6].
• A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex [7].
• We conclude that Lis1/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release [8].

Anatomical context of Dmn

• This suggests differences in the dynactin-mediated organelle binding by IC isoforms [9].
• Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons [10].
• GFP-Rod coimmunoprecipitates with dynein/dynactin, and in the absence of microtubules both Rod and dynactin accumulate on kinetochores [5].
• Dynactin affects extension and assembly of adherens junctions in Drosophila photoreceptor development [11].
• Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila [6].

Associations of Dmn with chemical compounds

• Despite evident structural differences in the heme distal pockets, the distinct molecular mechanisms regulating O2 binding to the three insect Hbs result in similar O(2 affinities (P50 values ranging between 0.12 torr and 0.46 torr) [12].

Analytical, diagnostic and therapeutic context of Dmn

• In order to characterize the role of the dynactin complex in the development and function of vertebrate neurons, the distribution of the p150Glued message was examined via in situ hybridization to serial sections of adult rat brain and to a developmental series of sections [13].

References