The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dmn  -  Dynamitin

Drosophila melanogaster

Synonyms: CG8269, DMN, Dmel\CG8269, P50, dDyn, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on Dmn

  • RESULTS: We analyzed dynein function in the oocyte by disrupting motor activity through temporally restricted expression of the dynactin subunit, dynamitin [1].

High impact information on Dmn


Biological context of Dmn


Anatomical context of Dmn


Associations of Dmn with chemical compounds

  • Despite evident structural differences in the heme distal pockets, the distinct molecular mechanisms regulating O2 binding to the three insect Hbs result in similar O(2 affinities (P50 values ranging between 0.12 torr and 0.46 torr) [12].

Analytical, diagnostic and therapeutic context of Dmn

  • In order to characterize the role of the dynactin complex in the development and function of vertebrate neurons, the distribution of the p150Glued message was examined via in situ hybridization to serial sections of adult rat brain and to a developmental series of sections [13].


  1. The cytoplasmic dynein and kinesin motors have interdependent roles in patterning the Drosophila oocyte. Duncan, J.E., Warrior, R. Curr. Biol. (2002) [Pubmed]
  2. Mutant dynactin in motor neuron disease. Puls, I., Jonnakuty, C., LaMonte, B.H., Holzbaur, E.L., Tokito, M., Mann, E., Floeter, M.K., Bidus, K., Drayna, D., Oh, S.J., Brown, R.H., Ludlow, C.L., Fischbeck, K.H. Nat. Genet. (2003) [Pubmed]
  3. Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein. Wojcik, E., Basto, R., Serr, M., Scaërou, F., Karess, R., Hays, T. Nat. Cell Biol. (2001) [Pubmed]
  4. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. Hoogenraad, C.C., Akhmanova, A., Howell, S.A., Dortland, B.R., De Zeeuw, C.I., Willemsen, R., Visser, P., Grosveld, F., Galjart, N. EMBO J. (2001) [Pubmed]
  5. In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Basto, R., Scaerou, F., Mische, S., Wojcik, E., Lefebvre, C., Gomes, R., Hays, T., Karess, R. Curr. Biol. (2004) [Pubmed]
  6. Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila. Ghosh-Roy, A., Kulkarni, M., Kumar, V., Shirolikar, S., Ray, K. Mol. Biol. Cell (2004) [Pubmed]
  7. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Boylan, K., Serr, M., Hays, T. Mol. Biol. Cell (2000) [Pubmed]
  8. Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Siller, K.H., Serr, M., Steward, R., Hays, T.S., Doe, C.Q. Mol. Biol. Cell (2005) [Pubmed]
  9. Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicing. Nurminsky, D.I., Nurminskaya, M.V., Benevolenskaya, E.V., Shevelyov, Y.Y., Hartl, D.L., Gvozdev, V.A. Mol. Cell. Biol. (1998) [Pubmed]
  10. Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons. Whited, J.L., Cassell, A., Brouillette, M., Garrity, P.A. Development (2004) [Pubmed]
  11. Dynactin affects extension and assembly of adherens junctions in Drosophila photoreceptor development. Fan, S.S. J. Biomed. Sci. (2004) [Pubmed]
  12. Modulation of oxygen binding to insect hemoglobins: the structure of hemoglobin from the botfly Gasterophilus intestinalis. Pesce, A., Nardini, M., Dewilde, S., Hoogewijs, D., Ascenzi, P., Moens, L., Bolognesi, M. Protein Sci. (2005) [Pubmed]
  13. Expression of the p150Glued component of the dynactin complex in developing and adult rat brain. Melloni, R.H., Tokito, M.K., Holzbaur, E.L. J. Comp. Neurol. (1995) [Pubmed]
WikiGenes - Universities