The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHLORDIMEFORM     N'-(4-chloro-2-methyl- phenyl)-N,N-dimethyl...

Synonyms: Galecron, Ovatoxin, Ovatoxion, Acaron, Bermat, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CHLORDIMEFORM


Psychiatry related information on CHLORDIMEFORM

  • There was a positive correlation between fundal MT and latency period (r=0.43, P=0.02) that persisted after adjusting for GA (P=.04) [5].
  • Cholecystokinin produced dose-dependent increases in motor activity in antral and fundal pouches of isolated guinea-pig stomachs [6].
  • Food deprivation for up to 22 h had no effect on fundal PGBC . In the antrum, a 12-hour fast caused a significant reduction in PGBC while a 22-hour fast had no effect [7].
  • A difference from human development was that zone 3 in the mouse, in both the meatal plate- and the fundal extension plate-derived areas, formed adnexal structures [8].
  • Deep dyspareunia intensity was higher in women with fundal and anterior myomas than in those with other myoma positions [9].

High impact information on CHLORDIMEFORM

  • Bladder biopsy specimens from three affected persons showed severe hemorrhagic cystitis; chlordimeform and 2-methyl-4-chloroaniline, a metabolite of chlordimeform, were present in urine specimens collected three days after exposure [1].
  • Gastroesophageal varices (GOV) are classified as GOV1 (EV extending down to cardia or lesser curve) or GOV2 (esophageal and fundal varices) [2].
  • Fundal height--can we trust the umbilicus [10]?
  • Fundal, antral, and duodenal mucosae were submitted to endoscopic examinations, and the antral mucosa underwent histologic examination before and after injury [11].
  • The retinal features sought on fundal photographs were the percentages of arteriovenous crossings with venule nipping, venule deviation, or attenuation of venular light reflex [12].

Chemical compound and disease context of CHLORDIMEFORM

  • The influence of fundal gastritis on the location, healing, and recurrence of gastric ulcers was studied by the endoscopic Congo red test [3].
  • Three patterns of retinopathy were discerned: 4 patients had disc vasculitis, 6 had multiple cotton-wool spots, and 5 had a normal fundal appearance but fluorescein leakage on angiography [13].
  • In one patient the adenocarcinoma obviously originated in a fundal polyp, and in the others the tumors could have arisen in mucosal areas not adequately responding to progesterone [14].
  • Twenty-four patients had F2 type varices and 7 had F3 type, classified according to the Japanese Research Society for Portal Hypertension. Seventeen patients had cardiofornical varices, and 14 had fundal varices [15].
  • When the fundal luminal pH was below pH 3, antral mucosal surface pH was 4.79 +/- 0.41 (24) in endoscopically normal subjects and significantly less (P less than 0.001) than the value of 6.98 +/- 0.18 (12) for gastric ulcer patients [16].

Biological context of CHLORDIMEFORM


Anatomical context of CHLORDIMEFORM

  • Biopsy specimens taken from the strictures demonstrated inflamed or ulcerated gastric fundal-type mucosa in both cases [22].
  • These ulcers were associated with little or no fundal gastritis, whereas ulcers in the pyloric gland area were usually associated with moderate or severe fundal gastritis [23].
  • We observed a marked increase in levels of PR-C and transcriptionally active PR-B specifically in fundal myometrium of women in labor [24].
  • The human gastric fundal mucosa contains a variety of endocrine cells, the most numerous of which are the so-called enterochromaffin-like (ECL) cells [25].
  • Retinopathy was assessed by seven-field stereoscopic fundal photography, albumin excretion rate (AER) from three consecutive timed overnight urine collections, peripheral nerve function by thermal and vibration thresholds, and autonomic nerve function by cardiovascular reflexes [26].

Associations of CHLORDIMEFORM with other chemical compounds


Gene context of CHLORDIMEFORM


Analytical, diagnostic and therapeutic context of CHLORDIMEFORM


  1. Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform. Folland, D.S., Kimbrough, R.D., Cline, R.E., Swiggart, R.C., Schaffner, W. JAMA (1978) [Pubmed]
  2. A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices. Ryan, B.M., Stockbrugger, R.W., Ryan, J.M. Gastroenterology (2004) [Pubmed]
  3. Location, healing, and recurrence of gastric ulcers in relation to fundal gastritis. Tatsuta, M., Okuda, S. Gastroenterology (1975) [Pubmed]
  4. Progression of fundal gastritis in gastric ulcer patients. Maaroos, H.I., Salupere, V., Uibo, R., Kekki, M., Sipponen, P. Gastroenterology (1986) [Pubmed]
  5. Sonographic myometrial thickness predicts the latency interval of women with preterm premature rupture of the membranes and oligohydramnios. Buhimschi, C.S., Buhimschi, I.A., Norwitz, E.R., Sfakianaki, A.K., Hamar, B., Copel, J.A., Saade, G.R., Weiner, C.P. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  6. Pressure-responses to cholecystokinin in the fundus and antrum of isolated guinea-pig stomachs. Gerner, T., Maehlumshagen, P., Haffner, J.F. Scand. J. Gastroenterol. (1976) [Pubmed]
  7. Prostaglandin biosynthesis by gastric mucosa. I. Studies in rat. Wallace, J.L., McCready, D.R., Chin, B.C., Track, N.S., Cohen, M.M. Clin. Biochem. (1984) [Pubmed]
  8. Auditory epithelial migration. III. Development of the stratified squamous epithelium of the tympanic membrane and external canal in the mouse. Michaels, L., Soucek, S. Am. J. Anat. (1991) [Pubmed]
  9. Uterine myomas, dyspareunia, and sexual function. Ferrero, S., Abbamonte, L.H., Giordano, M., Parisi, M., Ragni, N., Remorgida, V. Fertil. Steril. (2006) [Pubmed]
  10. Fundal height--can we trust the umbilicus? Royburt, M., Seidman, D.S. Lancet (1991) [Pubmed]
  11. Sucralfate protection of human gastric mucosa against acute ethanol injury. Cohen, M.M., Bowdler, R., Gervais, P., Morris, G.P., Wang, H.R. Gastroenterology (1989) [Pubmed]
  12. Usefulness of ophthalmoscopy in mild to moderate hypertension. Dimmitt, S.B., West, J.N., Eames, S.M., Gibson, J.M., Gosling, P., Littler, W.A. Lancet (1989) [Pubmed]
  13. SLE retinopathy: evaluation by fluorescein angiography. Lanham, J.G., Barrie, T., Kohner, E.M., Hughes, G.R. Ann. Rheum. Dis. (1982) [Pubmed]
  14. Origin of carcinoma in secretory endometrium--a study using a whole-organ sectioning technique. Risberg, B., Gröntoft, O., Westholm, B. Gynecol. Oncol. (1983) [Pubmed]
  15. Evaluation of magnetic resonance angiography in detection of gastric varices. Sato, T., Yamazaki, K., Toyota, J., Karino, Y., Ohmura, T., Suga, T. J. Gastroenterol. (1999) [Pubmed]
  16. Gastroduodenal mucosal surface and luminal pH in gastric ulcer. Rawlings, J.W., Danesh, B.J., Lucas, M.L., Morgan, R.J., Main, A.N., Russell, R.I. Dig. Dis. Sci. (1991) [Pubmed]
  17. An Xp22 microdeletion associated with ocular albinism and ichthyosis: approximation of breakpoints and estimation of deletion size by using cloned DNA probes and flow cytometry. Schnur, R.E., Trask, B.J., van den Engh, G., Punnett, H.H., Kistenmacher, M., Tomeo, M.A., Naids, R.E., Nussbaum, R.L. Am. J. Hum. Genet. (1989) [Pubmed]
  18. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Elovitz, M.A., Wang, Z., Chien, E.K., Rychlik, D.F., Phillippe, M. Am. J. Pathol. (2003) [Pubmed]
  19. Small bowel resistances and the gastroduodenal brake. Parr, N.J., Grime, J.S., Baxter, J.N., Critchley, M., Mackie, C.R. Gut (1987) [Pubmed]
  20. Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Katelaris, P.H., Seow, F., Lin, B.P., Napoli, J., Ngu, M.C., Jones, D.B. Gut (1993) [Pubmed]
  21. Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs. Dilawari, J.B., Newman, A., Poleo, J., Misiewicz, J.J. Gut (1975) [Pubmed]
  22. High esophageal stricture: a complication of "inlet patch" mucosa. Steadman, C., Kerlin, P., Teague, C., Stephenson, P. Gastroenterology (1988) [Pubmed]
  23. Gastric ulcers in the fundic gland area. Tatsuta, M., Okuda, S. Gastroenterology (1976) [Pubmed]
  24. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Condon, J.C., Hardy, D.B., Kovaric, K., Mendelson, C.R. Mol. Endocrinol. (2006) [Pubmed]
  25. Enterochromaffin-like cell populations in human fundic mucosa: quantitative studies of their variations with age, sex, and plasma gastrin levels. Green, D.M., Bishop, A.E., Rindi, G., Lee, F.I., Daly, M.J., Domin, J., Bloom, S.R., Polak, J.M. J. Pathol. (1989) [Pubmed]
  26. Discordant trends in microvascular complications in adolescents with type 1 diabetes from 1990 to 2002. Mohsin, F., Craig, M.E., Cusumano, J., Chan, A.K., Hing, S., Lee, J.W., Silink, M., Howard, N.J., Donaghue, K.C. Diabetes Care (2005) [Pubmed]
  27. Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. Blanks, A.M., Vatish, M., Allen, M.J., Ladds, G., de Wit, N.C., Slater, D.M., Thornton, S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  28. Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations. Lee, K.Y., Koh, A.H., Aung, T., Yong, V.H., Yeung, K., Ang, C.L., Vithana, E.N. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  29. Cotton-wool exudates not observed in recipients of renal transplants treated with cyclosporine. Oechslin, M., Thiel, G., Landmann, J., Gloor, B. Transplantation (1986) [Pubmed]
  30. Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths. Kinnamon, S.C., Klaassen, L.W., Kammer, A.E., Claassen, D. J. Neurobiol. (1984) [Pubmed]
  31. Body temperature-dependent and independent actions of chlordimeform on visual evoked potentials and axonal transport in optic system of rat. Boyes, W.K., Padilla, S., Dyer, R.S. Neuropharmacology (1985) [Pubmed]
  32. Expression of transient receptor channel proteins in human fundal myometrium in pregnancy. Ku, C.Y., Babich, L., Word, R.A., Zhong, M., Ulloa, A., Monga, M., Sanborn, B.M. J. Soc. Gynecol. Investig. (2006) [Pubmed]
  33. Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. Hosaka, N., Sasaki, T., Adachi, K., Sato, T., Tanaka, T., Miura, Y., Sawai, T., Toki, J., Hisha, H., Okamura, A., Takasu, K., Ikehara, S. Hum. Pathol. (2004) [Pubmed]
  34. Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. Zhang, T., O'Keefe, S.J., Winter, T., Marks, I.N., Ogden, J. Dig. Dis. Sci. (1998) [Pubmed]
  35. Balloon endoscopic sclerotherapy, a novel treatment for high-risk gastric fundal varices: a pilot study. Matsumoto, A., Hamamoto, N., Kayazawa, M. Gastroenterology (1999) [Pubmed]
  36. Pseudo-Zollinger--Ellison syndrome in a child presenting with anemia. Zaatar, R., Younoszai, M.K., Mitros, F. Gastroenterology (1987) [Pubmed]
  37. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. McLaughlin, J., Grazia Lucà, M., Jones, M.N., D'Amato, M., Dockray, G.J., Thompson, D.G. Gastroenterology (1999) [Pubmed]
  38. "Salvage" transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Chau, T.N., Patch, D., Chan, Y.W., Nagral, A., Dick, R., Burroughs, A.K. Gastroenterology (1998) [Pubmed]
WikiGenes - Universities