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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

CHLORDIMEFORM     N'-(4-chloro-2-methyl- phenyl)-N,N-dimethyl...

Synonyms: Galecron, Ovatoxin, Ovatoxion, Acaron, Bermat, ...
 
 
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Disease relevance of CHLORDIMEFORM

 

Psychiatry related information on CHLORDIMEFORM

  • There was a positive correlation between fundal MT and latency period (r=0.43, P=0.02) that persisted after adjusting for GA (P=.04) [5].
  • Cholecystokinin produced dose-dependent increases in motor activity in antral and fundal pouches of isolated guinea-pig stomachs [6].
  • Food deprivation for up to 22 h had no effect on fundal PGBC . In the antrum, a 12-hour fast caused a significant reduction in PGBC while a 22-hour fast had no effect [7].
  • A difference from human development was that zone 3 in the mouse, in both the meatal plate- and the fundal extension plate-derived areas, formed adnexal structures [8].
  • Deep dyspareunia intensity was higher in women with fundal and anterior myomas than in those with other myoma positions [9].
 

High impact information on CHLORDIMEFORM

  • Bladder biopsy specimens from three affected persons showed severe hemorrhagic cystitis; chlordimeform and 2-methyl-4-chloroaniline, a metabolite of chlordimeform, were present in urine specimens collected three days after exposure [1].
  • Gastroesophageal varices (GOV) are classified as GOV1 (EV extending down to cardia or lesser curve) or GOV2 (esophageal and fundal varices) [2].
  • Fundal height--can we trust the umbilicus [10]?
  • Fundal, antral, and duodenal mucosae were submitted to endoscopic examinations, and the antral mucosa underwent histologic examination before and after injury [11].
  • The retinal features sought on fundal photographs were the percentages of arteriovenous crossings with venule nipping, venule deviation, or attenuation of venular light reflex [12].
 

Chemical compound and disease context of CHLORDIMEFORM

  • The influence of fundal gastritis on the location, healing, and recurrence of gastric ulcers was studied by the endoscopic Congo red test [3].
  • Three patterns of retinopathy were discerned: 4 patients had disc vasculitis, 6 had multiple cotton-wool spots, and 5 had a normal fundal appearance but fluorescein leakage on angiography [13].
  • In one patient the adenocarcinoma obviously originated in a fundal polyp, and in the others the tumors could have arisen in mucosal areas not adequately responding to progesterone [14].
  • Twenty-four patients had F2 type varices and 7 had F3 type, classified according to the Japanese Research Society for Portal Hypertension. Seventeen patients had cardiofornical varices, and 14 had fundal varices [15].
  • When the fundal luminal pH was below pH 3, antral mucosal surface pH was 4.79 +/- 0.41 (24) in endoscopically normal subjects and significantly less (P less than 0.001) than the value of 6.98 +/- 0.18 (12) for gastric ulcer patients [16].
 

Biological context of CHLORDIMEFORM

 

Anatomical context of CHLORDIMEFORM

  • Biopsy specimens taken from the strictures demonstrated inflamed or ulcerated gastric fundal-type mucosa in both cases [22].
  • These ulcers were associated with little or no fundal gastritis, whereas ulcers in the pyloric gland area were usually associated with moderate or severe fundal gastritis [23].
  • We observed a marked increase in levels of PR-C and transcriptionally active PR-B specifically in fundal myometrium of women in labor [24].
  • The human gastric fundal mucosa contains a variety of endocrine cells, the most numerous of which are the so-called enterochromaffin-like (ECL) cells [25].
  • Retinopathy was assessed by seven-field stereoscopic fundal photography, albumin excretion rate (AER) from three consecutive timed overnight urine collections, peripheral nerve function by thermal and vibration thresholds, and autonomic nerve function by cardiovascular reflexes [26].
 

Associations of CHLORDIMEFORM with other chemical compounds

 

Gene context of CHLORDIMEFORM

 

Analytical, diagnostic and therapeutic context of CHLORDIMEFORM

References

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  3. Location, healing, and recurrence of gastric ulcers in relation to fundal gastritis. Tatsuta, M., Okuda, S. Gastroenterology (1975) [Pubmed]
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  12. Usefulness of ophthalmoscopy in mild to moderate hypertension. Dimmitt, S.B., West, J.N., Eames, S.M., Gibson, J.M., Gosling, P., Littler, W.A. Lancet (1989) [Pubmed]
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  14. Origin of carcinoma in secretory endometrium--a study using a whole-organ sectioning technique. Risberg, B., Gröntoft, O., Westholm, B. Gynecol. Oncol. (1983) [Pubmed]
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  17. An Xp22 microdeletion associated with ocular albinism and ichthyosis: approximation of breakpoints and estimation of deletion size by using cloned DNA probes and flow cytometry. Schnur, R.E., Trask, B.J., van den Engh, G., Punnett, H.H., Kistenmacher, M., Tomeo, M.A., Naids, R.E., Nussbaum, R.L. Am. J. Hum. Genet. (1989) [Pubmed]
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  22. High esophageal stricture: a complication of "inlet patch" mucosa. Steadman, C., Kerlin, P., Teague, C., Stephenson, P. Gastroenterology (1988) [Pubmed]
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  24. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Condon, J.C., Hardy, D.B., Kovaric, K., Mendelson, C.R. Mol. Endocrinol. (2006) [Pubmed]
  25. Enterochromaffin-like cell populations in human fundic mucosa: quantitative studies of their variations with age, sex, and plasma gastrin levels. Green, D.M., Bishop, A.E., Rindi, G., Lee, F.I., Daly, M.J., Domin, J., Bloom, S.R., Polak, J.M. J. Pathol. (1989) [Pubmed]
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