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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IGF1R  -  insulin-like growth factor 1 receptor

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High impact information on IGF1R

  • The presence of insulin and IGF-1 receptor binding site subtypes is not correlated with structurally different receptor binding subunits since only a single population of binding subunits is observed (apparent molecular weight of 125 +/- 2.7 kD) in embryonic and adult sclera.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • In mammalian cells, the insulin receptor substrate 1 protein (IRS-1) is a specific substrate for insulin and IGF-1 receptor tyrosine kinases which is involved in mediating metabolic and mitogenic actions of insulin and IGFs [2].
  • This is the first description of a common molecular mechanism, involving the MAPK ERK1/2, by which LHRH-R and IGF-1-R induce LH secretion in ovine pituitary cells [3].
  • Insulin and insulin-like growth factor-1 (IGF-1) both stimulated AIB uptake, but the higher concentrations of insulin necessary to increase uptake to a level comparable to that of IGF-1 stimulation suggested that insulin could be acting through the IGF-1 receptor [4].

References

  1. Insulin and IGF-1 binding in chick sclera. Waldbillig, R.J., Arnold, D.R., Fletcher, R.T., Chader, G.J. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  2. Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC). Taouis, M., Dupont, J., Gillet, A., Derouet, M., Simon, J. Mol. Cell. Endocrinol. (1998) [Pubmed]
  3. Molecular mechanisms involved in LH release by the ovine pituitary cells. Yang, D., Caraty, A., Dupont, J. Domest. Anim. Endocrinol. (2005) [Pubmed]
  4. Sodium ion-dependent (N-methylamino)-alpha-isobutyric [correction of isobutryic] acid uptake by embryonic chick cells exposed to ethanol in ovo:response to the stimulation/downregulation of protein kinases. Shibley, I.A., Pennington, S.N. Alcohol Alcohol. (1998) [Pubmed]
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