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Gene Review

Igf1r  -  insulin-like growth factor 1 receptor

Rattus norvegicus

Synonyms: IGF-I receptor, IGFIRC, Igfr1, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, ...
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Disease relevance of Igf1r


Psychiatry related information on Igf1r


High impact information on Igf1r


Chemical compound and disease context of Igf1r


Biological context of Igf1r


Anatomical context of Igf1r

  • The dynamics of IGF-I receptor (IGF-IR) activation were examined in freshly isolated rat hepatocytes [18].
  • In animal models of diabetes, diabetic myocardium is associated with decreased abundance of Hsp60, increased ubiquitination of IGF-1R, and lower level of IGF-1R protein [2].
  • In a mixed culture system that employed IGF-I receptor null murine embryo fibroblasts (MEFs) (R(-) cells) to detect paracrine signals produced by MEFs expressing the human IGF-I receptor (R(+) cells), stimulation of R(+) cells provoked rapid activation of green fluorescent protein-tagged ERK2 in cocultured R(-) cells [19].
  • Once induced, the Sm-C/IGF-I receptor of the granulosa cell required the continued presence of either FSH or LH for its maintenance; the lactogenic receptor agonist PRL had no effect.(ABSTRACT TRUNCATED AT 400 WORDS)[20]
  • Significantly, little or no variation was observed for basal Sm-C/IGF-I binding over the course of the experiment, suggesting that this component of Sm-C/IGF-I receptor complement may be independent of the trophic influence(s) of the pituitary gland [20].

Associations of Igf1r with chemical compounds

  • Igf1r expression was suppressed by both high- and low- glucose concentration [21].
  • The present study was undertaken to evaluate the expression of Igf2 and Igf1r transcript by RT-PCR in the post-implantation embryos obtained after paternal tamoxifen treatment [14].
  • We conclude that the endogenous IGF-I receptor has a specific antiapoptotic signalling capacity, that overexpression of other tyrosine kinases can allow them also to be antiapoptotic, and that activation of PI3 kinase and Akt is sufficient for antiapoptotic signalling [22].
  • IGF-I receptor mRNA is also abundant in TALs, but, in addition, is distributed throughout the distal nephron and collecting duct, and in the glomerulus, with lowest levels found in proximal tubules [15].
  • Treatment of C6 cells with 200 microg/ml Poly(IC) for 24 h reduced IGF-I receptor mRNA levels to 50% of the control level [17].

Physical interactions of Igf1r

  • Insulin-like growth factor (IGF)-binding proteins and the IGF-I receptor in rat kidney were studied to gain perspective on their potential roles in the control of renal cell mass [9].
  • To test whether hormonal regulation of IGF-I receptor (IGF-IR) and IGF binding protein-2 (IGFBP-2) may be involved in the accumulation of IGF-I in tanycytes, we assessed the effect of ovarian hormones on the levels of these molecules in the mediobasal hypothalamus of adult female rats [23].

Enzymatic interactions of Igf1r

  • Glutamate induces loss of sensitivity to IGF-I by phosphorylating the IGF-I receptor docking protein insulin-receptor-substrate (IRS)-1 in Ser(307) through a pathway involving activation of PKA and PKC in a hierarchical fashion [24].

Regulatory relationships of Igf1r


Other interactions of Igf1r

  • Antiapoptotic signalling by the IGF-I receptor depended on receptor kinase activity, as cells overexpressing kinase-defective receptor mutants could not be protected by IGF-I [22].
  • The antiapoptotic capacity of the IGF-I receptor was not shared by other growth factors tested, including epidermal growth factor (EGF) and thrombin, although the cells expressed functional receptors for all the agonists [22].
  • Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion [21].
  • Our results suggest that in the case of DNA synthesis the effects of IGF-II are mediated via the IGF-I receptor and those of insulin via the insulin receptor, whereas in the case of glycogenesis both are mediated via the insulin receptor [28].
  • In general, Hx resulted in decreased IGF-I and increased IGFBP-1 mRNA levels, and GH treatment produced the opposite effects, while IGF-I receptor mRNA levels were not significantly effected by either treatment [15].

Analytical, diagnostic and therapeutic context of Igf1r


  1. Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney. Werner, H., Shen-Orr, Z., Stannard, B., Burguera, B., Roberts, C.T., LeRoith, D. Diabetes (1990) [Pubmed]
  2. Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy. Shan, Y.X., Yang, T.L., Mestril, R., Wang, P.H. J. Biol. Chem. (2003) [Pubmed]
  3. Upregulation of cardiac insulin-like growth factor-I receptor by ACE inhibition after myocardial infarction: potential role in remodeling. Dean, R.G., Bach, L.A., Burrell, L.M. J. Histochem. Cytochem. (2003) [Pubmed]
  4. Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis. Wang, X.Z., Chen, Z.X., Zhang, L.J., Chen, Y.X., Li, D., Chen, F.L., Huang, Y.H. World J. Gastroenterol. (2003) [Pubmed]
  5. Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat. Phillip, M., Palese, T., Hernandez, E.R., Roberts, C.T., LeRoith, D., Kowarski, A.A. Endocrinology (1992) [Pubmed]
  6. Dexamethasone enhances insulin-like growth factor-I effects on skeletal muscle cell proliferation. Role of specific intracellular signaling pathways. Giorgino, F., Smith, R.J. J. Clin. Invest. (1995) [Pubmed]
  7. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. Bondy, C.A., Zhou, J., Chin, E., Reinhardt, R.R., Ding, L., Roth, R.A. J. Clin. Invest. (1994) [Pubmed]
  8. Extracellular matrix composition influences insulinlike growth factor I receptor expression in rat IEC-18 cells. Benya, R.V., Duncan, M.D., Mishra, L., Bass, B.L., Voyles, N.R., Korman, L.Y. Gastroenterology (1993) [Pubmed]
  9. Insulin-like growth factor-I receptor and binding proteins in rat kidney after nephron loss. Hise, M.K., Lahn, J.S., Shao, Z.M., Mantzouris, N.M., Fontana, J.A. J. Am. Soc. Nephrol. (1993) [Pubmed]
  10. Participation of growth factor signal transduction pathways in estradiol facilitation of female reproductive behavior. Etgen, A.M., Acosta-Martinez, M. Endocrinology (2003) [Pubmed]
  11. Insulin-like growth factor I administration in young rats with acute renal failure. Medina, A., Fernández-Fuente, M., Carbajo-Pérez, E., Santos, F., Amil, B., Rodríguez, J., Crespo, M. Pediatr. Nephrol. (2002) [Pubmed]
  12. IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Peretz, S., Kim, C., Rockwell, S., Baserga, R., Glazer, P.M. Radiat. Res. (2002) [Pubmed]
  13. Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat. Shynlova, O., Tsui, P., Dorogin, A., Langille, B.L., Lye, S.J. Biol. Reprod. (2007) [Pubmed]
  14. Effect of paternal tamoxifen on the expression of insulin-like growth factor 2 and insulin-like growth factor type 1 receptor in the post-implantation rat embryos. Kedia, N., Gill-Sharma, M.K., Parte, P., Juneja, H.S., Balasinor, N. Mol. Reprod. Dev. (2004) [Pubmed]
  15. Anatomical relationships in the patterns of insulin-like growth factor (IGF)-I, IGF binding protein-1, and IGF-I receptor gene expression in the rat kidney. Chin, E., Zhou, J., Bondy, C. Endocrinology (1992) [Pubmed]
  16. Growth hormone action on proliferation and differentiation of cerebral cortical cells from fetal rat. Ajo, R., Cacicedo, L., Navarro, C., Sánchez-Franco, F. Endocrinology (2003) [Pubmed]
  17. Double-stranded ribonucleic acid decreases C6 rat glioma cell numbers: effects on insulin-like growth factor I gene expression and action. Chacko, M.S., Adamo, M.L. Endocrinology (2000) [Pubmed]
  18. Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hallak, H., Moehren, G., Tang, J., Kaou, M., Addas, M., Hoek, J.B., Rubin, R. Hepatology (2002) [Pubmed]
  19. Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. El-Shewy, H.M., Kelly, F.L., Barki-Harrington, L., Luttrell, L.M. Mol. Endocrinol. (2004) [Pubmed]
  20. In vivo regulation of granulosa cell somatomedin-C/insulin-like growth factor I receptors. Adashi, E.Y., Resnick, C.E., Hernandez, E.R., Svoboda, M.E., Van Wyk, J.J. Endocrinology (1988) [Pubmed]
  21. Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells. Raile, K., Klammt, J., Laue, S., Garten, A., Blüher, M., Kralisch, S., Klöting, N., Kiess, W. Diabetologia (2005) [Pubmed]
  22. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Kulik, G., Klippel, A., Weber, M.J. Mol. Cell. Biol. (1997) [Pubmed]
  23. Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats. Cardona-G¿omez, G.P., Chowen, J.A., Garcia-Segura, L.M. J. Neurobiol. (2000) [Pubmed]
  24. Glutamate excitotoxicity attenuates insulin-like growth factor-I prosurvival signaling. Garcia-Galloway, E., Arango, C., Pons, S., Torres-Aleman, I. Mol. Cell. Neurosci. (2003) [Pubmed]
  25. Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells. Topalli, I., Etgen, A.M. Brain Res. (2004) [Pubmed]
  26. Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Tsukazaki, T., Usa, T., Matsumoto, T., Enomoto, H., Ohtsuru, A., Namba, H., Iwasaki, K., Yamashita, S. Exp. Cell Res. (1994) [Pubmed]
  27. Transcriptional regulation of the insulin-like growth factor-I receptor gene: evidence for protein kinase C-dependent and -independent pathways. Du, J., Meng, X.P., Delafontaine, P. Endocrinology (1996) [Pubmed]
  28. Insulin-like growth factor (IGF) binding proteins modulate the glucocorticoid-dependent biological effects of IGF-II in cultured fetal rat hepatocytes. Menuelle, P., Babajko, S., Plas, C. Endocrinology (1999) [Pubmed]
  29. Insulin-like growth factor I: a mitogen for rat Schwann cells in the presence of elevated levels of cyclic AMP. Schumacher, M., Jung-Testas, I., Robel, P., Baulieu, E.E. Glia (1993) [Pubmed]
  30. Role of receptors for epidermal growth factor and insulin-like growth factors I and II in the differentiation of rat mammary glands from lactogenesis I to lactogenesis II. Bussmann, L.E., Bussmann, I.M., Charreau, E.H. J. Reprod. Fertil. (1996) [Pubmed]
  31. Cortisol represses insulin-like growth factor II receptor transcription in skeletal cell cultures. Rydziel, S., Canalis, E. Endocrinology (1995) [Pubmed]
  32. Castration-induced apoptosis in the rat ventral prostate is associated with increased expression of genes encoding insulin-like growth factor binding proteins 2,3,4 and 5. Nickerson, T., Pollak, M., Huynh, H. Endocrinology (1998) [Pubmed]
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