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Gene Review

Ntrk3  -  neurotrophic tyrosine kinase, receptor,...

Rattus norvegicus

Synonyms: GP145-TrkC, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor type 3, Trk-C, TrkC tyrosine kinase, ...
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Disease relevance of Ntrk3


Psychiatry related information on Ntrk3


High impact information on Ntrk3

  • Actions of the truncated TrkB receptor did not involve unmasking of endogenous TrkC signaling [6].
  • To determine whether neurotrophins act on functionally distinct populations of adult sensory neurons, the distributions of mRNAs for TrkA and tyrosine kinase-containing isoforms of TrkB and TrkC were determined in rat DRG neurons projecting to different peripheral targets [7].
  • Stable and transient expression of TrkC receptors in PC12 cells indicates that the neurite outgrowth response elicited by NT-3 is dramatic in receptors lacking the novel kinase insert (gp150trkC) but absent in receptors containing the 14 amino acid insert in the kinase domain (gp150trkC14) [8].
  • Finally, forms of TrkC containing insertions within the kinase domain retain their ability to autophosphorylate in response to neurotrophin-3, but cannot mediate proliferation in fibroblasts or neuronal differentiation in PC12 cells [9].
  • Other forms of TrkC contain variable-sized amino acid insertions within the tyrosine kinase domain [9].

Biological context of Ntrk3


Anatomical context of Ntrk3


Associations of Ntrk3 with chemical compounds

  • No significant alterations to the expression of TrkC mRNA were found indicating that ethanol-exposure appears to act selectively on the BDNF communication system [19].
  • Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA [20].
  • A Western blot of CG-4 and C6 probed with antibody to a TrkC revealed the presence of gp145-kDa protein band [1].

Enzymatic interactions of Ntrk3

  • However, we found the TrkC receptor constitutively phosphorylated even in the absence of added ligand suggesting an interaction of TrkC with endogenously produced NT-3 [11].

Regulatory relationships of Ntrk3

  • Here we have studied whether this difference can be attributed to the presence of alternative TrkC receptor variants on the granule neurons and which signaling pathway is specifically activated by BDNF but not by NT-3 in these neurons [11].
  • Our results demonstrate that NT-3 at any concentration sufficient to activate the TrkC receptor results in a transient phosphorylation of the receptor and of Akt due, in part, to downregulation of the Trk receptor [21].

Other interactions of Ntrk3


Analytical, diagnostic and therapeutic context of Ntrk3


  1. Neurotrophin activates signal transduction in oligodendroglial cells: expression of functional TrkC receptor isoforms. Kumar, S., de Vellis, J. J. Neurosci. Res. (1996) [Pubmed]
  2. Presence and localization of neurotrophin receptor tyrosine kinase (TrkA, TrkB, TrkC) mRNAs in visceral afferent neurons of the nodose and petrosal ganglia. Zhuo, H., Helke, C.J. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  3. NGF, NT-3 and Trk C mRNAs, but not TrkA mRNA, are upregulated in the paraventricular structures in experimental hydrocephalus. Shinoda, M., Hidaka, M., Lindqvist, E., Söderström, S., Matsumae, M., Oi, S., Sato, O., Tsugane, R., Ebendal, T., Olson, L. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (2001) [Pubmed]
  4. Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord. Ying, Z., Roy, R.R., Edgerton, V.R., Gómez-Pinilla, F. Brain Res. (2003) [Pubmed]
  5. Endogenous neurotrophin-3 supports the survival of a subpopulation of sensory neurons in neonatal rat. Zhou, X.F., Cameron, D., Rush, R.A. Neuroscience (1998) [Pubmed]
  6. Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Yacoubian, T.A., Lo, D.C. Nat. Neurosci. (2000) [Pubmed]
  7. Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. McMahon, S.B., Armanini, M.P., Ling, L.H., Phillips, H.S. Neuron (1994) [Pubmed]
  8. The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Tsoulfas, P., Soppet, D., Escandon, E., Tessarollo, L., Mendoza-Ramirez, J.L., Rosenthal, A., Nikolics, K., Parada, L.F. Neuron (1993) [Pubmed]
  9. Alternative forms of rat TrkC with different functional capabilities. Valenzuela, D.M., Maisonpierre, P.C., Glass, D.J., Rojas, E., Nuñez, L., Kong, Y., Gies, D.R., Stitt, T.N., Ip, N.Y., Yancopoulos, G.D. Neuron (1993) [Pubmed]
  10. Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Rudge, J.S., Li, Y., Pasnikowski, E.M., Mattsson, K., Pan, L., Yancopoulos, G.D., Wiegand, S.J., Lindsay, R.M., Ip, N.Y. Eur. J. Neurosci. (1994) [Pubmed]
  11. Constitutive phosphorylation of TrkC receptors in cultured cerebellar granule neurons might be responsible for the inability of NT-3 to increase neuronal survival and to activate p21 Ras. Zirrgiebel, U., Lindholm, D. Neurochem. Res. (1996) [Pubmed]
  12. Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. Kryl, D., Yacoubian, T., Haapasalo, A., Castren, E., Lo, D., Barker, P.A. J. Neurosci. (1999) [Pubmed]
  13. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E.M., Chan, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo. Kumar, S., Kahn, M.A., Dinh, L., de Vellis, J. J. Neurosci. Res. (1998) [Pubmed]
  15. Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N.J., Ryan, T.E., Acheson, A., Lindsay, R.M., Persson, H., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Ríos, J.D., Ghinelli, E., Gu, J., Hodges, R.R., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  17. Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension. Rudzinski, M., Wong, T.P., Saragovi, H.U. J. Neurobiol. (2004) [Pubmed]
  18. Neurotrophin receptor immunostaining in the vestibular nuclei of rats. Zhang, F.X., Lai, C.H., Lai, S.K., Yung, K.K., Shum, D.K., Chan, Y.S. Neuroreport (2003) [Pubmed]
  19. Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum. Light, K.E., Ge, Y., Belcher, S.M. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  20. Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity. Kavanaugh, B., Beesley, J., Itoh, T., Itoh, A., Grinspan, J., Pleasure, D. J. Neurosci. Res. (2000) [Pubmed]
  21. IGF-I and NT-3 signaling pathways in developing oligodendrocytes: differential regulation and activation of receptors and the downstream effector Akt. Ness, J.K., Mitchell, N.E., Wood, T.L. Dev. Neurosci. (2002) [Pubmed]
  22. Brain-derived neurotrophic factor and neurotrophin-3 enhance somatostatin gene expression through a likely direct effect on hypothalamic somatostatin neurons. Rage, F., Riteau, B., Alonso, G., Tapia-Arancibia, L. Endocrinology (1999) [Pubmed]
  23. Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat. Lee, P., Zhuo, H., Helke, C.J. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  24. Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. Chalazonitis, A., Rothman, T.P., Chen, J., Lamballe, F., Barbacid, M., Gershon, M.D. J. Neurosci. (1994) [Pubmed]
  25. Decreased expression of TrkB and TrkC mRNAs in spinal motoneurons of aged rats. Johnson, H., Hökfelt, T., Ulfhake, B. Eur. J. Neurosci. (1996) [Pubmed]
  26. Ontogeny of neurotrophin receptor trkC expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus. Hassink, G.C., van Esseveldt, K.E., Dijkhuizen, P.A., Verhaagen, J., Boer, G.J. Neuroscience (1999) [Pubmed]
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