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Gene Review

NTRK2  -  neurotrophic tyrosine kinase, receptor,...

Gallus gallus

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Disease relevance of NTRK2

  • BDNF labeling was found over all layers in the retina, whereas TrkB labeling was intense over cells in the ganglion cell layer, which is in agreement with the response of ganglion cells to BDNF stimulation [1].

High impact information on NTRK2

  • BDNF is first expressed in both the pigment epithelium and neural retina of embryonic day 4 embryos, and at the same stage of development, its TrkB receptor is expressed in the neural retina [2].
  • In situ localization with an extracellular domain probe common to all TrkB transcripts labeled a sub-population of large retinal ganglion cells as well as many associated visual nuclei, including the neuronal layers within the tectum that receive retinal innervation [3].
  • In chicken embryonic retina and optic tectum we detected full-length TrkB and TrkC; however, the optic tectum also expressed large amounts of the truncated form of TrkB [4].
  • Full-length TrkB and TrkC receptors were found in chicken and rat embryonic ventral spinal cord, as well as on purified motoneurons [4].
  • However, this desensitization was not observed in a transformed cell line expressing TrkB [5].

Biological context of NTRK2

  • Because BDNF is expressed in both the retina and tectum, it is conceivable that TrkB also mediates autocrine/paracrine signaling within these structures or anterograde retinotectal trophic support [3].
  • Treatment with BDNF resulted in significant down-regulation of TrkB mRNA levels (P<0.05) at E10 but not E8 or E15 [6].

Anatomical context of NTRK2

  • TrkC but not TrkB was detected in chicken embryonic skeletal muscle, suggesting that NT-3 may have a novel function in this tissue [4].
  • Truncated TrkB receptors may regulate the BDNF concentration available to neurites, and they might have an important role during reinnervation [7].
  • In addition, mRNA for the truncated TrkB receptor was expressed in nonneuronal cells, specifically in supporting cells, located adjacent to the site of BDNF synthesis and nerve endings [7].
  • Expression and function of brain-derived neurotrophin factor and its receptor, TrkB, in ovarian follicles from the domestic hen (Gallus gallus domesticus) [8].
  • This pattern of expression suggests a paracrine relationship between theca and granulosa cells for BDNF signaling via TrkB [8].

Associations of NTRK2 with chemical compounds

  • Since the expression of its receptor TrkB can be induced by the transcriptional activator retinoic acid (RA), we have investigated the possibility that RA promotes axonal regeneration of differentiated chick RGC synergistically with BDNF [9].

Other interactions of NTRK2


Analytical, diagnostic and therapeutic context of NTRK2


  1. Expression of neurotrophins and trk receptors in the avian retina. Hallböök, F., Bäckström, A., Kullander, K., Ebendal, T., Carri, N.G. J. Comp. Neurol. (1996) [Pubmed]
  2. Control of early cell death by BDNF in the chick retina. Frade, J.M., Bovolenta, P., Martínez-Morales, J.R., Arribas, A., Barbas, J.A., Rodríguez-Tébar, A. Development (1997) [Pubmed]
  3. Expression of TrkB receptor isoforms in the developing avian visual system. Garner, A.S., Menegay, H.J., Boeshore, K.L., Xie, X.Y., Voci, J.M., Johnson, J.E., Large, T.H. J. Neurosci. (1996) [Pubmed]
  4. Regulation of neurotrophin receptor expression during embryonic and postnatal development. Escandón, E., Soppet, D., Rosenthal, A., Mendoza-Ramírez, J.L., Szönyi, E., Burton, L.E., Henderson, C.E., Parada, L.F., Nikolics, K. J. Neurosci. (1994) [Pubmed]
  5. Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor. Carter, B.D., Zirrgiebel, U., Barde, Y.A. J. Biol. Chem. (1995) [Pubmed]
  6. BDNF and NT-3 regulation of trkB and trkC mRNA levels in the developing chick spinal cord. Gibbons, A.S., Bailey, K.A. Neurosci. Lett. (2005) [Pubmed]
  7. Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea. Pirvola, U., Hallböök, F., Xing-Qun, L., Virkkala, J., Saarma, M., Ylikoski, J. J. Neurobiol. (1997) [Pubmed]
  8. Expression and function of brain-derived neurotrophin factor and its receptor, TrkB, in ovarian follicles from the domestic hen (Gallus gallus domesticus). Jensen, T., Johnson, A.L. J. Exp. Biol. (2001) [Pubmed]
  9. Retinoic acid increases BDNF-dependent regeneration of chick retinal ganglion cells in vitro. Mey, J., Rombach, N. Neuroreport (1999) [Pubmed]
  10. Neurotrophins and their receptors in chicken neuronal development. Hallbook, F., Bäckström, A., Kullander, K., Kylberg, A., Williams, R., Ebendal, T. Int. J. Dev. Biol. (1995) [Pubmed]
  11. Ontogenetic expression of trk neurotrophin receptors in the chick auditory system. Cochran, S.L., Stone, J.S., Bermingham-McDonogh, O., Akers, S.R., Lefcort, F., Rubel, E.W. J. Comp. Neurol. (1999) [Pubmed]
  12. Cloning and sequence analysis of a cDNA encoding a novel truncated form of the chicken TrkB receptor. Vinh, N.Q., Erdmann, K.S., Heumann, R. Gene (1994) [Pubmed]
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