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Gene Review

mex1  -  midgut expression 1

Drosophila melanogaster

Synonyms: CG7936, Dmel\CG7936, Protein midgut expression 1
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High impact information on mex1

  • The tachykinin-related peptide prohormone gene (Dtk) is both expressed and post-translationally processed in larval and adult midgut endocrine cells and in the central nervous system, with midgut expression starting at stage 17 of embryogenesis [1].
  • The Drosophila mex1 gene is one of several genes clustered within a 10-kb interval of polytene region 71CD that includes the ecdysone-regulated Eip28/29 gene. mex1 is expressed in several developmental stages, with gene transcripts accumulating initially in 9- to 12-hr embryos [2].
  • During embryogenesis, mex1 exhibits an endoderm-specific pattern of expression. mex1 transcripts are first detected in the anterior and posterior midgut primordia of stage 12 embryos; subsequently, mex1 mRNA accumulates solely in the differentiating embryonic midgut [2].
  • DNA sequence analysis reveals that the mex1 gene encodes an unusual cysteine-rich polypeptide [2].
  • In addition to the silencer, another element is located downstream of the Adh gene that produces a higher level of anterior than posterior midgut expression [3].

Associations of mex1 with chemical compounds


Other interactions of mex1

  • The mex1 mutant allele is associated with statistically significant decreases in malic enzyme (ME) specific activity and ME specific immunologically cross-reacting material (ME-CRM) in newly emerged adult males [4].


  1. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A. Siviter, R.J., Coast, G.M., Winther, A.M., Nachman, R.J., Taylor, C.A., Shirras, A.D., Coates, D., Isaac, R.E., Nässel, D.R. J. Biol. Chem. (2000) [Pubmed]
  2. Endoderm-specific expression of the Drosophila mex1 gene. Schulz, R.A., Xie, X., Andres, A.J., Galewsky, S. Dev. Biol. (1991) [Pubmed]
  3. Isolation of silencer-containing sequences causing a tissue-specific position effect on alcohol dehydrogenase expression in Drosophila melanogaster. Kirkpatrick, R.B., Parveen, Z., Martin, P.F. Dev. Genet. (1994) [Pubmed]
  4. The isolation and characterization of mutant alleles at a new X-linked locus, mex, affecting NADP(+)-dependent enzymes in Drosophila melanogaster. Gromnicki, A.R., Bentley, M.M. Biochem. Genet. (1991) [Pubmed]
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