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Gene Review

Pgd  -  Phosphogluconate dehydrogenase

Drosophila melanogaster

Synonyms: 6-PGD, 6-Pgd, 6-pgd, 6-phosphogluconate dehydrogenase, decarboxylating, 6PGD, ...
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High impact information on Pgd

  • While a null activity mutant allele of the structural gene for 6-phosphogluconate dehydrogenase in Drosophila melanogaster is lethal, a similar mutation for glucose-6-phosphate dehydrogenase is not [1].
  • Taken together, the results of these experiments show that different genotypes of 6Pgd are associated with measurable biochemical and physiological differences [2].
  • However, in situ hybridization of rat tissues demonstrated more restricted expression of Rel-N1 mRNA within a subset of neurons of the hippocampus, cortex, and other regions of the gray matter, but not in glial cells or white matter [3].
  • We measured four-cutter DNA restriction site and allozyme variation at Pgd among 142 D. melanogaster X chromosomes collected from several geographic regions including North Carolina, California, and Zimbabwe (Africa) [4].
  • Since the Pgd region appears to have low rates of crossing over, the reduced level of variation at this locus supports the idea that recombination rates are important determinants of levels of DNA polymorphism in natural populations [4].

Biological context of Pgd


Anatomical context of Pgd

  • Only 421 bp of Pgd+ 5'-flanking DNA are necessary to direct expression in imaginal discs, gonads and gut of third-instar larvae [6].
  • To characterize the cis-acting sequences necessary for expression of Pgd+, fragments containing this gene as well as Pgd+ promoter-lacZ fusions were introduced into the D. melanogaster germ line by P-element-mediated transformation [6].
  • Using recombinant lines, we obtained data that suggested the existence of more than one gene on chromosome III involved in the regulation of G6PD in the fat body, and at least one of these genes affects the level of 6PGD as well [8].
  • The chromosomal location of the genes for 6PGD and G6PD were determined by in situ hybridization to salivary gland polytene chromosomes [9].

Associations of Pgd with chemical compounds


Other interactions of Pgd

  • In this case, the pn, wapl and Pgd loci no longer variegate, suggesting that the satellite-containing h34 region is not able per se to induce detectable PEV on the adjacent euchromatic genes [12].
  • We found five parallel latitudinal clines for AdhF and three clines for GpdhS in five geographic regions as well as four clines for G6pdF, three clines for Est-6S, and two clines for OdhF and PgdF in four regions (data from South America for G6pd, Odh, Est-6, and Pgd were not available) [13].
  • Nevertheless, adult alphaGPDH, and larval IDH and 6PGDH activities exhibited significant differences between the two populations [14].
  • Furthermore, while patterns of allozyme variation are very similar at Pgd and Adh, the DNA data show that the evolutionary histories of these genes are dramatically different [4].
  • Established chromosomal arm homologies of Muller's element A are only partly supported by present results since two of the probes (Pgd and zeste) hybridize at the proximal end of the XR chromosomal arm in the three Nearctic species [15].


  1. Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster. Hughes, M.B., Lucchesi, J.C. Science (1977) [Pubmed]
  2. Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster. Cavener, D.R., Clegg, M.T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  3. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. King, P.H., Levine, T.D., Fremeau, R.T., Keene, J.D. J. Neurosci. (1994) [Pubmed]
  4. Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of drosophila: selection and geographic differentiation. Begun, D.J., Aquadro, C.F. Genetics (1994) [Pubmed]
  5. Survivorship and gene frequencies of Drosophila melanogaster populations in abnormal oxygen atmospheres. Kloek, G.P., Ralin, D.B., Ridgel, G.C. Aviation, space, and environmental medicine. (1976) [Pubmed]
  6. Structure and expression of the Drosophila melanogaster gene encoding 6-phosphogluconate dehydrogenase. Scott, M.J., Lucchesi, J.C. Gene (1991) [Pubmed]
  7. Lethal effects of low and "null" activity alleles of 6-phosphogluconate dehydrogenase in Drosophila melanogaster. Bewley, G.C., Lucchesi, J.G. Genetics (1975) [Pubmed]
  8. Regulation of enzyme activities in Drosophila: genetic variation affecting induction of glucose 6-phosphate and 6-phosphogluconate dehydrogenase in larvae. Cochrane, B.J., Lucchesi, J.C., Laurie-Ahlberg, C.C. Genetics (1983) [Pubmed]
  9. Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5. Scott, M.J., Kriticou, D., Robinson, A.S. Insect Mol. Biol. (1993) [Pubmed]
  10. The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster. Bijlsma, R., Kerver, J.W. Genetics (1983) [Pubmed]
  11. Stress responses in alfalfa (Medicago sativa L.) XIX. Transcriptional activation of oxidative pentose phosphate pathway genes at the onset of the isoflavonoid phytoalexin response. Fahrendorf, T., Ni, W., Shorrosh, B.S., Dixon, R.A. Plant Mol. Biol. (1995) [Pubmed]
  12. Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement. Tolchkov, E.V., Kramerova, I.A., Lavrov, S.A., Rasheva, V.I., Bonaccorsi, S., Alatortsev, V.E., Gvozdev, V.A. Chromosoma (1997) [Pubmed]
  13. Geographic variation of six allozyme loci in Drosophila melanogaster: an analysis of data from different continents. Bubliy, O.A., Kalabushkin, B.A., Imasheva, A.G. Hereditas (1999) [Pubmed]
  14. Structure of variation in enzyme activity in natural Drosophila melanogaster populations. Pecsenye, K., Saura, A. Hereditas (2002) [Pubmed]
  15. Molecular organization of the X chromosome in different species of the obscura group of Drosophila. Segarra, C., Aguadé, M. Genetics (1992) [Pubmed]
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