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Gene Review

Zw  -  Zwischenferment

Drosophila melanogaster

Synonyms: CG12529, Dmel\CG12529, G-6-PD, G-6-pdh, G-6PD, ...
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High impact information on Zw


Biological context of Zw


Anatomical context of Zw

  • Using recombinant lines, we obtained data that suggested the existence of more than one gene on chromosome III involved in the regulation of G6PD in the fat body, and at least one of these genes affects the level of 6PGD as well [10].
  • Confirmation that the Drosophila DNA fragment cloned in lambda DmG21 contains the G6PD gene sequence is based on the following observations. lambda DmG21 DNA shows hybridization only to the 18D region of the salivary gland X-chromosome, which is the known cytological locus for the G6PD gene [11].

Associations of Zw with chemical compounds


Other interactions of Zw


Analytical, diagnostic and therapeutic context of Zw


  1. Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster. Hughes, M.B., Lucchesi, J.C. Science (1977) [Pubmed]
  2. Evidence for adaptive evolution of the G6pd gene in the Drosophila melanogaster and Drosophila simulans lineages. Eanes, W.F., Kirchner, M., Yoon, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Short-range genetic structure of Drosophila melanogaster populations in an Afrotropical urban area and its significance. Vouidibio, J., Capy, P., Defaye, D., Pla, E., Sandrin, J., Csink, A., David, J.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster. Cavener, D.R., Clegg, M.T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. Restriction-map variation associated with the G6PD polymorphism in natural populations of Drosophila melanogaster. Eanes, W.F., Ajioka, J.W., Hey, J., Wesley, C. Mol. Biol. Evol. (1989) [Pubmed]
  6. Historical selection, amino acid polymorphism and lineage-specific divergence at the G6pd locus in Drosophila melanogaster and D. simulans. Eanes, W.F., Kirchner, M., Yoon, J., Biermann, C.H., Wang, I.N., McCartney, M.A., Verrelli, B.C. Genetics (1996) [Pubmed]
  7. Nucleotide sequence of the Drosophila glucose-6-phosphate dehydrogenase gene and comparison with the homologous human gene. Fouts, D., Ganguly, R., Gutierrez, A.G., Lucchesi, J.C., Manning, J.E. Gene (1988) [Pubmed]
  8. Molecular and phenotypic variation of the Zw locus region in Drosophila melanogaster. Miyashita, N.T. Genetics (1990) [Pubmed]
  9. Viability interactions, in vivo activity and the G6PD polymorphism in Drosophila melanogaster. Eanes, W.F. Genetics (1984) [Pubmed]
  10. Regulation of enzyme activities in Drosophila: genetic variation affecting induction of glucose 6-phosphate and 6-phosphogluconate dehydrogenase in larvae. Cochrane, B.J., Lucchesi, J.C., Laurie-Ahlberg, C.C. Genetics (1983) [Pubmed]
  11. Isolation and characterization of the glucose-6-phosphate dehydrogenase gene of Drosophila melanogaster. Ganguly, R., Ganguly, N., Manning, J.E. Gene (1985) [Pubmed]
  12. The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster. Bijlsma, R., Kerver, J.W. Genetics (1983) [Pubmed]
  13. Targeted selection experiments and enzyme polymorphism: negative evidence for octanoate selection at the G6PD locus in Drosophila melanogaster. Eanes, W.F., Bingham, B., Hey, J., Houle, D. Genetics (1985) [Pubmed]
  14. Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture. Hamblin, M.T., Veuille, M. Genetics (1999) [Pubmed]
  15. Cloning of genes by mRNA differential display induced during the hypersensitive reaction of soybean after inoculation with Pseudomonas syringae pv. glycinea. Seehaus, K., Tenhaken, R. Plant Mol. Biol. (1998) [Pubmed]
  16. The isolation and characterization of mutant alleles at a new X-linked locus, mex, affecting NADP(+)-dependent enzymes in Drosophila melanogaster. Gromnicki, A.R., Bentley, M.M. Biochem. Genet. (1991) [Pubmed]
  17. Transcriptional activation of the Drosophila melanogaster glucose-6-phosphate dehydrogenase gene by insertion of defective P elements. Ito, H., Hamabata, T., Hori, S.H. Mol. Gen. Genet. (1993) [Pubmed]
  18. Isolation of cDNAs encoding 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase from the mediterranean fruit fly Ceratitis capitata: correlating genetic and physical maps of chromosome 5. Scott, M.J., Kriticou, D., Robinson, A.S. Insect Mol. Biol. (1993) [Pubmed]
  19. Four tandem defective P elements associated with positive regulation of the Drosophila melanogaster glucose-6-phosphate dehydrogenase gene. Itoh, M., Iwabuchi, M., Yoshida, K., Hori, S.H. Biochem. Genet. (1989) [Pubmed]
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