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Gene Review

Tk  -  Tachykinin

Drosophila melanogaster

Synonyms: CG14734, DTK, DTK-1, DTK-2, DTK-3, ...
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Psychiatry related information on Tk


High impact information on Tk


Biological context of Tk


Anatomical context of Tk


Associations of Tk with chemical compounds

  • Vertebrate tachykinins (or neurokinins) did not evoke any effect at concentrations up to 10(-5) M, but an antagonist of mammalian neurokinin receptors, spantide II, inhibited the Lom-TK III-induced calcium response [4].
  • A few naturally occurring insect tachykinin-related peptides, such as stomoxytachykinin (Stc-TK), contain an Ala-residue instead of the highly conserved Gly-residue that is present in most other members of this peptide family [8].
  • Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned STKR cDNA [9].
  • An aminoisobutyric acid-containing analogue of the cockroach tachykinin-related peptide, LemTRP-1, with potent bioactivity and resistance to an insect angiotensin-converting enzyme [10].
  • The functional assay based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca(2+) levels was used to examine and compare the effect of tachykinin-related peptides from different species [11].

Regulatory relationships of Tk

  • DTKR was activated by all Drosophila tachykinins and inhibited by tachykinin antagonists [12].

Other interactions of Tk


Analytical, diagnostic and therapeutic context of Tk

  • A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein [17].


  1. Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila. Winther, A.M., Acebes, A., Ferrús, A. Mol. Cell. Neurosci. (2006) [Pubmed]
  2. Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. Li, X.J., Wolfgang, W., Wu, Y.N., North, R.A., Forte, M. EMBO J. (1991) [Pubmed]
  3. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A. Siviter, R.J., Coast, G.M., Winther, A.M., Nachman, R.J., Taylor, C.A., Shirras, A.D., Coates, D., Isaac, R.E., Nässel, D.R. J. Biol. Chem. (2000) [Pubmed]
  4. Characterization of a receptor for insect tachykinin-like peptide agonists by functional expression in a stable Drosophila Schneider 2 cell line. Torfs, H., Shariatmadari, R., Guerrero, F., Parmentier, M., Poels, J., Van Poyer, W., Swinnen, E., De Loof, A., Akerman, K., Vanden Broeck, J. J. Neurochem. (2000) [Pubmed]
  5. Pharmacological characterization of STKR, an insect G protein-coupled receptor for tachykinin-like peptides. Torfs, H., Oonk, H.B., Broeck, J.V., Poels, J., Van Poyer, W., De Loof, A., Guerrero, F., Meloen, R.H., Akerman, K., Nachman, R.J. Arch. Insect Biochem. Physiol. (2001) [Pubmed]
  6. Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila. Winther, A.M., Siviter, R.J., Isaac, R.E., Predel, R., Nässel, D.R. J. Comp. Neurol. (2003) [Pubmed]
  7. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Isaac, R.E., Parkin, E.T., Keen, J.N., Nässel, D.R., Siviter, R.J., Shirras, A.D. Peptides (2002) [Pubmed]
  8. Substitution of conserved glycine residue by alanine in natural and synthetic neuropeptide ligands causes partial agonism at the stomoxytachykinin receptor. Poels, J., Van Loy, T., Franssens, V., Detheux, M., Nachman, R.J., Oonk, H.B., Akerman, K.E., Vassart, G., Parmentier, M., De Loof, A., Torfs, H., Broeck, J.V. J. Neurochem. (2004) [Pubmed]
  9. Pharmacology of stomoxytachykinin receptor depends on second messenger system. Poels, J., Nachman, R.J., Akerman, K.E., Oonk, H.B., Guerrero, F., De Loof, A., Janecka, A.E., Torfs, H., Vanden Broeck, J. Peptides (2005) [Pubmed]
  10. An aminoisobutyric acid-containing analogue of the cockroach tachykinin-related peptide, LemTRP-1, with potent bioactivity and resistance to an insect angiotensin-converting enzyme. Nachman, R.J., Muren, J.E., Isaac, R.E., Lundquist, C.T., Karlsson, A., Nässel, D.R. Regul. Pept. (1998) [Pubmed]
  11. Characterization of Tachykinin-related Peptides from Different Insect Species on Drosophila Tachykinin Receptor-expressing Cell Line. Fichna, J., Poels, J., Broeck, J.V., Janecka, A. Chemical biology & drug design (2006) [Pubmed]
  12. Functional comparison of two evolutionary conserved insect neurokinin-like receptors. Poels, J., Verlinden, H., Fichna, J., Van Loy, T., Franssens, V., Studzian, K., Janecka, A., Nachman, R.J., Broeck, J.V. Peptides (2007) [Pubmed]
  13. Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme. Siviter, R.J., Nachman, R.J., Dani, M.P., Keen, J.N., Shirras, A.D., Isaac, R.E. Peptides (2002) [Pubmed]
  14. Dual organisation of the Drosophila neuropeptide receptor NKD gene promoter. Rosay, P., Colas, J.F., Maroteaux, L. Mech. Dev. (1995) [Pubmed]
  15. Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. Li, X.J., Wu, Y.N., North, R.A., Forte, M. J. Biol. Chem. (1992) [Pubmed]
  16. Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry. Baggerman, G., Boonen, K., Verleyen, P., De Loof, A., Schoofs, L. Journal of mass spectrometry : JMS. (2005) [Pubmed]
  17. A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein. Johard, H.A., Muren, J.E., Nichols, R., Larhammar, D.S., Nässel, D.R. Brain Res. (2001) [Pubmed]
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