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Gene Review:

HSD17B4 - hydroxysteroid (17-beta) dehydrogenase 4

Sus scrofa

Husen, B. et al., de Launoit, Y. et al., Markus, M. et al., Möller, G. et al., Leenders, F. et al., et al.

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High impact information on HSD17B4

Unique multifunctional HSD17B4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome [1].
The peroxisomal 17beta-hydroxysteroid dehydrogenase type 4 (17beta-HSD 4, gene name HSD17B4) catalyzes the oxidation of estradiol with high preference over the reduction of estrone [1].
The N-terminal part reveals activities of 17beta-estradiol dehydrogenase type IV and D-specific 3-hydroxyacyl CoA dehydrogenase, the central part shows D-specific hydratase activity with straight and 2-methyl-branched 2-enoyl-CoAs [2].
Immunogold electron microscopy localizes 17 beta-estradiol dehydrogenase in organelles of 120 to 500 nm with moderate electron-dense matrices bounded by single membranes [3].
The tissue distribution of porcine 17 beta-estradiol dehydrogenase and its induction by progesterone [4].

Biological context of HSD17B4

Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase [5].
Alterations in the subcellular distribution of 17 beta-estradiol dehydrogenase in porcine endometrial cells over the course of the estrous cycle [6].

Anatomical context of HSD17B4

The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes [3].
The 17 beta-estradiol dehydrogenase of porcine endometrium was found to be localized in specialized particles [7].
The monoclonal antibody F1 against the structure-bound 17 beta-estradiol dehydrogenase of porcine endometrial epithelium was applied to rehydrated paraffin sections either as a direct, peroxidase-linked probe or in combination with a fluorescing secondary antibody [6].

Associations of HSD17B4 with chemical compounds

The sequence of porcine 80 kDa 17 beta-estradiol dehydrogenase reveals similarities to the short chain alcohol dehydrogenase family, to actin binding motifs and to sterol carrier protein 2 [8].

References

Unique multifunctional HSD17B4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome. de Launoit, Y., Adamski, J. J. Mol. Endocrinol. (1999) [Pubmed]
Peroxisome targeting of porcine 17beta-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI. Möller, G., Lüders, J., Markus, M., Husen, B., Van Veldhoven, P.P., Adamski, J. J. Cell. Biochem. (1999) [Pubmed]
The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes. Markus, M., Husen, B., Leenders, F., Jungblut, P.W., Hall, P.F., Adamski, J. Eur. J. Cell Biol. (1995) [Pubmed]
The tissue distribution of porcine 17 beta-estradiol dehydrogenase and its induction by progesterone. Kaufmann, M., Carstensen, J., Husen, B., Adamski, J. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase. Leenders, F., Adamski, J., Husen, B., Thole, H.H., Jungblut, P.W. Eur. J. Biochem. (1994) [Pubmed]
Alterations in the subcellular distribution of 17 beta-estradiol dehydrogenase in porcine endometrial cells over the course of the estrous cycle. Husen, B., Adamski, J., Szendro, P.I., Jungblut, P.W. Cell Tissue Res. (1994) [Pubmed]
Isolation of vesicles mediating the conversion of 17 beta-estradiol to estrone. Adamski, J. Eur. J. Cell Biol. (1991) [Pubmed]
The sequence of porcine 80 kDa 17 beta-estradiol dehydrogenase reveals similarities to the short chain alcohol dehydrogenase family, to actin binding motifs and to sterol carrier protein 2. Leenders, F., Husen, B., Thole, H.H., Adamski, J. Mol. Cell. Endocrinol. (1994) [Pubmed]

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