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abcb1  -  ATP-binding cassette, sub-family B...

Xenopus laevis

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High impact information on Xemdr


Biological context of Xemdr

  • A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis [4].
  • The predicted structure of the Xe-mdr gene product identifies twelve membrane spanning domains and two ATP binding sites both of which are the hallmark of the ABC (ATP binding cassette) transporters [4].

Anatomical context of Xemdr


  1. The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel. Schreiber, R., Hopf, A., Mall, M., Greger, R., Kunzelmann, K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles. Manzini, I., Schild, D. J. Physiol. (Lond.) (2003) [Pubmed]
  3. Failure of P-glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling-activated chloride channel activity. Morin, X.K., Bond, T.D., Loo, T.W., Clarke, D.M., Bear, C.E. J. Physiol. (Lond.) (1995) [Pubmed]
  4. A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis. Castillo, G., Shen, H.J., Horwitz, S.B. Biochim. Biophys. Acta (1995) [Pubmed]
  5. Functional expression of murine multidrug resistance in Xenopus laevis oocytes. Castillo, G., Vera, J.C., Yang, C.P., Horwitz, S.B., Rosen, O.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Identification of a multixenobiotic resistance mechanism in Xenopus laevis embryos. Bonfanti, P., Colombo, A., Camatini, M. Chemosphere (1998) [Pubmed]
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