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Gene Review

lhx3  -  LIM homeobox 3

Xenopus laevis

Synonyms: LIM-3, lim3, xlim-3
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High impact information on Xlim-3

  • Expression of LIM class homeobox gene Xlim-3 in Xenopus development is limited to neural and neuroendocrine tissues [1].
  • This discrete manner of Xlim-3 expression, especially persistent expression in the pituitary (before morphogenesis of the gland to adult), supports a role in the specification and maintenance of differentiation of distinct neuronal and neuroendocrine tissues [1].
  • The Xenopus LIM class homeobox gene Xlim-3 was identified initially as a fragment isolated by polymerase chain reaction cloning with an embryonic cDNA library as template (Taira et al., 1992, Genes Dev. 6, 356-366). cDNA clones representing most of the Xlim-3 mRNA were isolated from an adult brain library [1].
  • In situ hybridization analysis on serial sections at later stages showed that embryonic Xlim-3 expression persists in the pituitary and pineal, as well as in some cells of the retina, hindbrain, and spinal cord [1].
  • RNA blot hybridization showed that Xlim-3 mRNA is detected in dorsal regions at neural tube and tailbud stages and in adults predominantly in the pituitary gland and weakly in the eye and brain [1].

Biological context of Xlim-3

  • Exon 1a encodes a sequence similar to that of Xlim-3, whereas exon 1b encodes a different N-terminus [2].

Associations of Xlim-3 with chemical compounds


Analytical, diagnostic and therapeutic context of Xlim-3

  • Whole mount in situ hybridization revealed that Xlim-3 mRNA is first detectable at the neural plate stage in the stomodeal-hypophyseal (pituitary) anlage and in the neural plate where labeled cells were found adjacent to the forming floor plate [1].


  1. Expression of LIM class homeobox gene Xlim-3 in Xenopus development is limited to neural and neuroendocrine tissues. Taira, M., Hayes, W.P., Otani, H., Dawid, I.B. Dev. Biol. (1993) [Pubmed]
  2. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. Zhadanov, A.B., Bertuzzi, S., Taira, M., Dawid, I.B., Westphal, H. Dev. Dyn. (1995) [Pubmed]
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