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Gene Review

cby1  -  chibby homolog 1

Xenopus laevis

Synonyms: arb1, cby, chibby, pgea1, pigea-14, ...
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High impact information on LOC398327


Biological context of LOC398327

  • With 24 amino acids determining the affinities and kinetics of the interactions with three different partners, the leucine-rich motif is strongly established as one of the most potent and flexible protein--protein interaction motifs [6].

Associations of LOC398327 with chemical compounds


Analytical, diagnostic and therapeutic context of LOC398327


  1. CRM1 is an export receptor for leucine-rich nuclear export signals. Fornerod, M., Ohno, M., Yoshida, M., Mattaj, I.W. Cell (1997) [Pubmed]
  2. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M., Nishida, E. Nature (1997) [Pubmed]
  3. Regulation of protein phosphatase type 1 and cell cycle progression by PfLRR1, a novel leucine-rich repeat protein of the human malaria parasite Plasmodium falciparum. Daher, W., Browaeys, E., Pierrot, C., Jouin, H., Dive, D., Meurice, E., Dissous, C., Capron, M., Tomavo, S., Doerig, C., Cailliau, K., Khalife, J. Mol. Microbiol. (2006) [Pubmed]
  4. Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. Pengue, G., Calabrò, V., Bartoli, P.C., Pagliuca, A., Lania, L. Nucleic Acids Res. (1994) [Pubmed]
  5. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Haines, B.P., Wheldon, L.M., Summerbell, D., Heath, J.K., Rigby, P.W. Dev. Biol. (2006) [Pubmed]
  6. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB. Windisch, J.M., Marksteiner, R., Lang, M.E., Auer, B., Schneider, R. Biochemistry (1995) [Pubmed]
  7. Qualitative highly divergent nuclear export signals can regulate export by the competition for transport cofactors in vivo. Heger, P., Lohmaier, J., Schneider, G., Schweimer, K., Stauber, R.H. Traffic (2001) [Pubmed]
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