Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

carB - carbamoyl phosphate synthase large subunit

Escherichia coli UTI89

Velayos, A. et al., Lusty, C.J. et al., Ruiz-Hidalgo, M.J. et al., Velayos, A. et al.

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Disease relevance of carB

The cDNA and genomic copies complemented phytoene dehydrogenase defects in Escherichia coli and in carB mutants of M. circinelloides, respectively [1].

High impact information on carB

The recombinant plasmids with the yeast cpaII gene fail to cross-hybridize with a cloned fragment of E. coli DNA containing the carA and carB genes for the bacterial carbamoyl-phosphate synthetase [2].
Blue-light regulation of phytoene dehydrogenase (carB) gene expression in Mucor circinelloides [1].
The carRP gene is closely linked to the phytoene dehydrogenase (carB) gene, and the promoter regions of both genes are located within only 446 bp [3].

Analytical, diagnostic and therapeutic context of carB

By using a polymerase chain reaction based cloning strategy we isolated the gene (carB) encoding the enzyme phytoene dehydrogenase from Phycomyces blakesleeanus [4].

References

Blue-light regulation of phytoene dehydrogenase (carB) gene expression in Mucor circinelloides. Velayos, A., Blasco, J.L., Alvarez, M.I., Iturriaga, E.A., Eslava, A.P. Planta (2000) [Pubmed]
Cloning of a yeast gene coding for arginine-specific carbamoyl-phosphate synthetase. Lusty, C.J., Lu, J. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides. Velayos, A., Eslava, A.P., Iturriaga, E.A. Eur. J. Biochem. (2000) [Pubmed]
The phytoene dehydrogenase gene of Phycomyces: regulation of its expression by blue light and vitamin A. Ruiz-Hidalgo, M.J., Benito, E.P., Sandmann, G., Eslava, A.P. Mol. Gen. Genet. (1997) [Pubmed]

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