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Gene Review

entB  -  2,3-dihydro-2,3-dihydroxybenzoate synthetase

Escherichia coli UTI89

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Disease relevance of entB


High impact information on entB

  • Southern hybridization experiments showed that the entB gene was present on identical restriction fragments in the chromosomes of SEB-producer strains [1].
  • Maxam-Gilbert sequencing of a part of the entB gene yielded a DNA sequence that corresponds to the known amino acid sequence of SEB [1].
  • Plasmids isolated with Tn5 insertions in the 5' half of entB had the phenotype EntB- EntG+ [3].
  • The metabolic shift from one diene to the other is caused by a change in activity of isochorismate hydroxymutase and/or isochorismatase which in turn results from growth under iron deficiency or overexpression of genes (entC and/or entB) involved in chrismate metabolism [4].

Chemical compound and disease context of entB


Analytical, diagnostic and therapeutic context of entB

  • Southern blot data showed a Mu insertion, presumably with polar effects, in the vicinity of the 5' end of entB [3].


  1. Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus. Ranelli, D.M., Jones, C.L., Johns, M.B., Mussey, G.J., Khan, S.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Genetics and regulation of enterobactin genes in Shigella flexneri. Schmitt, M.P., Payne, S.M. J. Bacteriol. (1988) [Pubmed]
  3. EntG activity of Escherichia coli enterobactin synthetase. Staab, J.F., Earhart, C.F. J. Bacteriol. (1990) [Pubmed]
  4. Bacterial production of transdihydroxycyclohexadiene carboxylates by metabolic pathway engineering. Müller, R., Breuer, M., Wagener, A., Schmidt, K., Leistner, E. Microbiology (Reading, Engl.) (1996) [Pubmed]
  5. Subcloning of the enterobactin biosynthetic gene entB: expression, purification, characterization, and substrate specificity of isochorismatase. Rusnak, F., Liu, J., Quinn, N., Berchtold, G.A., Walsh, C.T. Biochemistry (1990) [Pubmed]
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