Gene Review:
pxna - paxillin a
Danio rerio
Synonyms:
SO:0000704, pxn, wu:fw71f12
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High impact information on pxn
- We investigated the focal adhesion proteins paxillin and Fak, and the cell-cell adhesion protein cadherin in developing zebrafish (Danio rerio) embryos [1].
- Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis [1].
- Novel observations showed that focal adhesion kinase and paxillin concentrate at sites of cell-cell adhesion in the epithelial enveloping layer and may associate with actin cytoskeleton at epithelial junctions containing cadherins [1].
- The initiation of somite formation coincides with an increase in the phosphorylation of Fak, and the accumulation of Fak, phosphorylated Fak, paxillin, and fibronectin at nascent somite boundaries [1].
Associations of pxn with chemical compounds
- These data suggest that Fak and paxillin may function in the integration of cadherin-based and integrin-based cell adhesion during the morphogenesis of the early zebrafish embryo [1].
References
- Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Crawford, B.D., Henry, C.A., Clason, T.A., Becker, A.L., Hille, M.B. Mol. Biol. Cell (2003) [Pubmed]
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