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Gene Review

ash1  -  absent, small, or homeotic discs 1

Drosophila melanogaster

Synonyms: ASH1, Absent small and homeotic disks protein 1, Ash, Ash 1, Ash1, ...


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High impact information on ash1


Biological context of ash1


Anatomical context of ash1

  • ASH1 was expressed both in embryonic proneural clusters--within which an individual cell retained ASH1 expression, enlarged, segregated, and became a neural precursor--and in larval wing discs in putative sensory mother cells [6].
  • The ASH1 protein is localized on polytene chromosomes of larval salivary glands at > 100 sites [7].

Associations of ash1 with chemical compounds

  • Two genes with mutant versions that act as dominant suppressors of the wing phenotype were identified: the PKA-C1/DCO gene, encoding the catalytic subunit of cyclic AMP protein kinase, and ash1, a member of the trithorax group (trxG) of chromatin modifiers [8].

Regulatory relationships of ash1

  • Using immunocolocalization, we showed that the ASH1 protein is specifically expressed in the majority of the dCBP-overexpressing cells, suggesting that these proteins have the potential to interact biochemically [8].

Other interactions of ash1

  • The gene Shal, which is located cytogenetically nearby ash1, was used to initiate an 84-kb genomic walk within which the ash1 gene was identified [5].
  • In this paper we examine the consequences of ash1 and ash2 mutations on the expression of homeotic selector genes in imaginal discs [9].
  • The absent, small or homeotic discs1 gene (ash1) is one of the trithorax set of genes [5].
  • The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins [10].


  1. Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Beisel, C., Imhof, A., Greene, J., Kremmer, E., Sauer, F. Nature (2002) [Pubmed]
  2. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Papp, B., Müller, J. Genes Dev. (2006) [Pubmed]
  3. ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Byrd, K.N., Shearn, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter. Rozovskaia, T., Tillib, S., Smith, S., Sedkov, Y., Rozenblatt-Rosen, O., Petruk, S., Yano, T., Nakamura, T., Ben-Simchon, L., Gildea, J., Croce, C.M., Shearn, A., Canaani, E., Mazo, A. Mol. Cell. Biol. (1999) [Pubmed]
  5. Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ash1). Tripoulas, N.A., Hersperger, E., La Jeunesse, D., Shearn, A. Genetics (1994) [Pubmed]
  6. Expression pattern of a butterfly achaete-scute homolog reveals the homology of butterfly wing scales and insect sensory bristles. Galant, R., Skeath, J.B., Paddock, S., Lewis, D.L., Carroll, S.B. Curr. Biol. (1998) [Pubmed]
  7. The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger. Tripoulas, N., LaJeunesse, D., Gildea, J., Shearn, A. Genetics (1996) [Pubmed]
  8. Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Bantignies, F., Goodman, R.H., Smolik, S.M. Mol. Cell. Biol. (2000) [Pubmed]
  9. Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2. LaJeunesse, D., Shearn, A. Mech. Dev. (1995) [Pubmed]
  10. The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins. Klymenko, T., Müller, J. EMBO Rep. (2004) [Pubmed]
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