High impact information on Deaf1

• Consistent with this hypothesis, we have discovered DEAF-1 binding sites in other Deformed response elements [1].
• Mutations in the response element designed to improve binding to DEAF-1 in vitro resulted in increased embryonic expression [1].
• This motif, first described for the Drosophila homeobox activator DEAF-1, identifies an emerging group of metazoan transcriptional modulators [2].
• We show that the DEAF-1 binding region is not required for enhancer function [3].
• The Drosophila protein DEAF-1 is a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd) [4].

Biological context of Deaf1

• Thus, DEAF-1 is likely to contribute to the functional activity, and perhaps to the homeotic specificity, of this response element [1].
• The 1.28 DRE contains in vitro binding sites for Deformed and DEAF-1 [3].
• DEAF-1 function is essential for the early embryonic development of Drosophila [4].
• The DEAF-1 protein associates with many discrete sites on polytene chromosomes, suggesting that DEAF-1 is a rather general regulator of gene expression [4].

Other interactions of Deaf1

• DEAF-1, a novel protein that binds an essential region in a Deformed response element [1].

References