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Gene Review

jing  -  CG9397 gene product from transcript CG9397-RI

Drosophila melanogaster

Synonyms: 1.28, CG9397, CG9403, CT9093, Dmel\CG9397, ...
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High impact information on 1.28


Biological context of 1.28


Associations of 1.28 with chemical compounds

  • As we predicted, methoprene phenocopies a subset of previously described BRC defects; it also phenocopies Deformed and produces abnormalities not associated with known mutations [7].

Physical interactions of 1.28


Other interactions of 1.28

  • DEAF-1, a novel protein that binds an essential region in a Deformed response element [3].
  • 01, and 0.62 +/- 0.06 microM, respectively. cGMP activation was cooperative with a Hill coefficient (nH) of 1.28 +/- 0.10, whereas activation by cAMP was not cooperative [8].
  • We propose that cnc functions in combination with the homeotic gene Deformed to specify mandibular development [9].
  • We undertook a deficiency screen in Drosophila melanogaster in an attempt to identify loci potentially encoding cofactors for the protein encoded by the HOM-C gene Deformed (Dfd) [10].
  • One of these genes, extradenticle, encodes a homeodomain transcription factor that heterodimerizes with Deformed and other homeotic Hox proteins [11].

Analytical, diagnostic and therapeutic context of 1.28

  • Here we describe a detailed functional dissection of a small element that is specifically regulated by the Deformed homeotic protein [12].


  1. Mapping functional specificity in the Dfd and Ubx homeo domains. Lin, L., McGinnis, W. Genes Dev. (1992) [Pubmed]
  2. High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene. Regulski, M., Dessain, S., McGinnis, N., McGinnis, W. Genes Dev. (1991) [Pubmed]
  3. DEAF-1, a novel protein that binds an essential region in a Deformed response element. Gross, C.T., McGinnis, W. EMBO J. (1996) [Pubmed]
  4. Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson, J.A., LaFollette, J.W., Gross, C., Veraksa, A., McGinnis, W., Mahaffey, J.W. Genetics (2000) [Pubmed]
  5. Further genetic variation at the esterase loci of Drosophila virilis. Tsuno, K., Aotsuka, N.T., Ohba, S. Biochem. Genet. (1984) [Pubmed]
  6. Identification and characterization of a gene activated by the deformed homeoprotein. Mahaffey, J.W., Jones, D.F., Hickel, J.A., Griswold, C.M. Development (1993) [Pubmed]
  7. A juvenile hormone agonist reveals distinct developmental pathways mediated by ecdysone-inducible broad complex transcription factors. Restifo, L.L., Wilson, T.G. Dev. Genet. (1998) [Pubmed]
  8. Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. Foster, J.L., Higgins, G.C., Jackson, F.R. J. Biol. Chem. (1996) [Pubmed]
  9. Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Mohler, J., Mahaffey, J.W., Deutsch, E., Vani, K. Development (1995) [Pubmed]
  10. The Drosophila genes disconnected and disco-related are redundant with respect to larval head development and accumulation of mRNAs from deformed target genes. Mahaffey, J.W., Griswold, C.M., Cao, Q.M. Genetics (2001) [Pubmed]
  11. A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function. Florence, B., McGinnis, W. Genetics (1998) [Pubmed]
  12. Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos. Zeng, C., Pinsonneault, J., Gellon, G., McGinnis, N., McGinnis, W. EMBO J. (1994) [Pubmed]
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