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Gene Review

dzip1  -  DAZ interacting zinc finger protein 1

Danio rerio

Synonyms: DAZ-interacting protein 1 homolog, Iguana protein, SO:0000704, Zinc finger protein Dzip1, igu, ...
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High impact information on dzip1

  • Here, using genetic analysis, we show that the zebrafish iguana gene product acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo [1].
  • Positional cloning reveals that iguana encodes the zebrafish ortholog of Dzip1, a novel zinc-finger/coiled-coil domain protein that we show can shuttle between the cytoplasm and nucleus in a manner correlated with Hedgehog pathway activity [1].
  • We also show that Hh target gene expression in igu mutants is resistant to increased protein kinase A activity that normally represses Hh signaling [2].
  • Mutations in igu lead to reduced expression of Hh target genes in the ventral neural tube, similar to the phenotype seen in zebrafish mutants known to affect Hh signaling [2].
  • Later development of the floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour, schmalhans and monorail embryos; these mutants often show additional defects in tissues that are known to depend on signals from notochord and floor plate [3].

Anatomical context of dzip1


Analytical, diagnostic and therapeutic context of dzip1

  • Genetic and pharmacological analyses revealed that the expression of Hh target genes in igu mutants requires Gli activator function but does not depend on Smoothened function [2].


  1. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. Genes Dev. (2004) [Pubmed]
  2. The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., Kawakami, A. Development (2004) [Pubmed]
  3. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  4. Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., Karlstrom, R.O. Mech. Dev. (2000) [Pubmed]
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