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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCL11  -  chemokine (C-C motif) ligand 11

Bos taurus

 
 
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Disease relevance of LOC404072

 

High impact information on LOC404072

  • We only detected faint eotaxin mRNA signals that did not indicate physiological significance even in stimulated granulosa cell cultures, follicle-derived macrophages or fibroblasts [1].
  • Both MVEC types expressed monocyte colony-stimulating factor mRNA, but remained negative for eotaxin and interleukin (IL)-5 mRNA even after stimulation [2].
 

Anatomical context of LOC404072

  • Thus, the chimeric structure of bovine eotaxin did not affect the favoured chemotactic activity on eosinophils [1].
 

Analytical, diagnostic and therapeutic context of LOC404072

  • Semiquantitative RT-PCR was used to investigate the expression of eotaxin in different regions of the bovine ovary [1].

References

  1. Bovine eotaxin (CCL11)--an unusual member of the eotaxin group--attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary. Vogel, B., Klinder, A., Sittig, D., Aust, G. Vet. Immunol. Immunopathol. (2005) [Pubmed]
  2. Microvascular endothelial cells differ in their basal and tumour necrosis factor-alpha-regulated expression of adhesion molecules and cytokines. Lehmann, I., Brylla, E., Sittig, D., Spanel-Borowski, K., Aust, G. J. Vasc. Res. (2000) [Pubmed]
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