Disease relevance of Ccl11

• Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro [1].
• We conclude that Sephadex induces pulmonary eosinophilia prior to blood eosinophilia and suggest that Sephadex may induce pulmonary release of one or more eosinophil chemotactic substance(s) [2].
• Eosinophil chemotactic factors associated with acute hypersensitivity reactions include the eosinophil chemotactic factors of anaphylaxis, histamine, and arachidonic acid metabolites, all of which are released from mast cells, and the lymphokine eosinophil stimulation promoter (ESP) [3].
• Regulation of eosinophilia in rats infected with Nippostrongylus brasiliensis. I. Eosinophil chemotactic factor produced spontaneously by mesenteric lymph node cells of infected rats [4].

High impact information on Ccl11

• Eosinophil chemotactic factor release from neutrophils by Nippostrongylus brasiliensis larvae [5].
• This enhancement of killer activity may be due to the generation by complement activation of eosinophil chemotactic factors which increase the concentration of cells at the target surface [6].
• N-Formylmethionylphenylalanine and valylglycylserylglutamic acid (eosinophil chemotactic Factor A) had significantly less chemoattractant activity over the same range of concentrations [7].
• Intermediate molecular weight eosinophil chemotactic factors in rat peritoneal mast cells: immunologic release, granule association, and demostration of structura heterogeneity [8].
• Although eosinophil chemotactic activity, determined by a modified Boyden chamber method, was present in the supernatant of cultured lymph node cells from young rats, it was absent from those of aged rats [9].

Chemical compound and disease context of Ccl11

• Using subagglutinating concentrations of antibody, the antibody-dependent cell cytotoxic response was significantly enhanced with FMLP, leukotriene B4, and eosinophil chemotactic factor of anaphylaxis [10].

Biological context of Ccl11

• During phagocytosis, histamine, beta-glucuronidase, and eosinophil chemotactic factor are released from mast cells in a time-, temperature- and dose-dependent fashion [11].

Anatomical context of Ccl11

• These findings demonstrate an anti-allergic effect of SC, and indicate that its anti-edematogenic effect is due to the inhibition of mast cell degranulation and of histamine and serotonin effects, whereas the inhibition of eosinophil accumulation in the allergic pleurisy model is probably due to an impairment of CCL11/eotaxin and IL-5 production [12].
• Estrogen regulation of an eosinophil chemotactic factor in the immature rat uterus [13].
• Dexamethasone blocked both the saline-induced eosinophil migration and the release of eosinophil chemotactic factor by mast cells and macrophages [14].
• A low molecular weight eosinophil chemotactic factor (ECF) which has previously been found within mast cells and polymorphonuclear cells is shown to be released from highly purified rat peritoneal macrophages on exposure to the calcium ionophore A 23187 or after phagocytosis of zymosan coated with complement (Z x) [15].
• Furthermore, Nb worm extract has no or only very weak in vitro eosinophil chemotactic activity, suggesting that parasite-derived eosinophil chemotactic factor (ECF) is, if at all, not a major regulator for intestinal tissue eosinophilia in this Nb rat system [4].

Associations of Ccl11 with chemical compounds

• Eosinophil chemotactic factor (ECF), previously thought to be primarily associated with human basophils and mast cells, could be released from human neutrophils (PMN) and eosinophils but not lymphocytes by the calcium ionophore A23187 [16].
• The ontogeny of an estrogen-induced eosinophil chemotactic activity in the uterus after estrogen administration and its regulation by progesterone was studied in neonatal rats at 3, 7, 10, and 13 days of age [17].
• Testosterone showed little effect on eosinophil chemotactic activity and did not inhibit the E2-stimulated synthesis of C3 [18].
• In addition we have demonstrated eosinophil chemotactic activity associated with metabolism of arachidonic acid by T. taeniaeformis metacestodes [3].
• Leukotriene B4 and neutrophil-derived eosinophil chemotactic factor: comparison of their biological activities [19].

Other interactions of Ccl11

• Eosinophil chemotactic peptide sequences in rat alpha-CGRP. Activation of a novel trophic action by neutral endopeptidase 24.11 [20].

Analytical, diagnostic and therapeutic context of Ccl11

• This effect was related to the inhibition of IL-5 (from 70.9 +/- 25.2 to 12.05 +/- 7.165 pg/mL) and CCL11/eotaxin levels (from 60.4 +/- 8.54 to 32.8 +/- 8.4 ng/mL) in pleural lavage fluid, using ELISA [12].
• Eosinophil chemotactic activity in bronchoalveolar lavage fluid obtained from Toxocara canis-infected rats [21].

References