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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

Terms

 

Gene Review: 

mao  -  monoamine oxidase

Danio rerio

Synonyms: MAO, Monoamine oxidase, SO:0000704, Z-MAO, maob, ...
 
 
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Disease relevance of mao

 

High impact information on mao

  • Both the mao mutation and pharmacological blockade of Na+ current reduced these signatures of the cell death program [2].
  • Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes [3].
  • This effect can be reversed by deprenyl, a specific inhibitor of monoamine oxidase B that catalyses the conversion of MPTP to its active metabolite, MPP+ [4].
  • The domain linking the FAD is very well conserved, while the transmembrane domain sequence linking the enzyme to the external mitochondrial membrane does not appear to be conserved even with respect to trout MAO [5].
  • The projection phenotype in mao as well as in the TTX-treated larvae develops between 4 and 6 d post-fertilization (dpf), after complete tectal coverage is first achieved [6].

References

  1. Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio). Anichtchik, O., Sallinen, V., Peitsaro, N., Panula, P. J. Comp. Neurol. (2006) [Pubmed]
  2. Activity regulates programmed cell death of zebrafish Rohon-Beard neurons. Svoboda, K.R., Linares, A.E., Ribera, A.B. Development (2001) [Pubmed]
  3. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  4. Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP. Lam, C.S., Korzh, V., Strahle, U. Eur. J. Neurosci. (2005) [Pubmed]
  5. Molecular characterization of monoamine oxidase in zebrafish (Danio rerio). Setini, A., Pierucci, F., Senatori, O., Nicotra, A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  6. Analysis of the activity-deprived zebrafish mutant macho reveals an essential requirement of neuronal activity for the development of a fine-grained visuotopic map. Gnuegge, L., Schmid, S., Neuhauss, S.C. J. Neurosci. (2001) [Pubmed]
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