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WIF1  -  WNT inhibitory factor 1

Homo sapiens

Synonyms: UNQ191/PRO217, WIF-1, Wnt inhibitory factor 1
 
 
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Disease relevance of WIF1

  • Furthermore, while for both SFRP-1 and WIF-1 methylation-associated silencing occurred across the whole spectrum of colorectal tumorigenesis, DKK-1 promoter was selectively hypermethylated in advanced colorectal neoplasms (Duke's C and D tumors) [1].
  • Recently, CpG island promoter hypermethylation was shown to cause inactivation of two extracellular Wnt inhibitors in colon cancer: secreted frizzled-related proteins (sFRPs) and Wnt inhibitory factor-1 (WIF-1) [1].
  • Our findings establish the WIF1 gene as a target for epigenetic silencing in breast cancer and provide a mechanistic link between the dysregulation of Wnt signaling and breast tumorigenesis [2].
  • To our knowledge, this is the first report suggesting that WIF1 is a recurrent target in human salivary gland oncogenesis and that downregulation of WIF1 plays a role in the development and/or progression of pleomorphic adenomas [3].
  • We screened 13 additional benign and malignant salivary gland tumors and detected WIF1 rearrangement in one out of two carcinomas ex-pleomorphic adenoma analyzed [3].
 

High impact information on WIF1

 

Chemical compound and disease context of WIF1

 

Biological context of WIF1

 

Anatomical context of WIF1

 

Associations of WIF1 with chemical compounds

 

Regulatory relationships of WIF1

  • In the present study, we found that WIF-1 downregulates the Akt pathway and also enhances chemosensitivity in PTEN-null Pca cells [10].
  • In normal salivary gland tissue WIF1 is expressed at a high level and HMGA2 is not expressed [3].
 

Other interactions of WIF1

References

  1. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Aguilera, O., Fraga, M.F., Ballestar, E., Paz, M.F., Herranz, M., Espada, J., García, J.M., Muñoz, A., Esteller, M., González-Sancho, J.M. Oncogene (2006) [Pubmed]
  2. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Ai, L., Tao, Q., Zhong, S., Fields, C.R., Kim, W.J., Lee, M.W., Cui, Y., Brown, K.D., Robertson, K.D. Carcinogenesis (2006) [Pubmed]
  3. WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. Queimado, L., Lopes, C.S., Reis, A.M. Genes Chromosomes Cancer (2007) [Pubmed]
  4. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Mazieres, J., He, B., You, L., Xu, Z., Lee, A.Y., Mikami, I., Reguart, N., Rosell, R., McCormick, F., Jablons, D.M. Cancer Res. (2004) [Pubmed]
  5. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Milutinovic, S., D'Alessio, A.C., Detich, N., Szyf, M. Carcinogenesis (2007) [Pubmed]
  6. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Taniguchi, H., Yamamoto, H., Hirata, T., Miyamoto, N., Oki, M., Nosho, K., Adachi, Y., Endo, T., Imai, K., Shinomura, Y. Oncogene (2005) [Pubmed]
  7. Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Urakami, S., Shiina, H., Enokida, H., Kawakami, T., Tokizane, T., Ogishima, T., Tanaka, Y., Li, L.C., Ribeiro-Filho, L.A., Terashima, M., Kikuno, N., Adachi, H., Yoneda, T., Kishi, H., Shigeno, K., Konety, B.R., Igawa, M., Dahiya, R. Clin. Cancer Res. (2006) [Pubmed]
  8. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Lin, Y.C., You, L., Xu, Z., He, B., Mikami, I., Thung, E., Chou, J., Kuchenbecker, K., Kim, J., Raz, D., Yang, C.T., Chen, J.K., Jablons, D.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Batra, S., Shi, Y., Kuchenbecker, K.M., He, B., Reguart, N., Mikami, I., You, L., Xu, Z., Lin, Y.C., Clément, G., Jablons, D.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Ohigashi, T., Mizuno, R., Nakashima, J., Marumo, K., Murai, M. Prostate (2005) [Pubmed]
  11. Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung. Tang, M., Torres-Lanzas, J., Lopez-Rios, F., Esteller, M., Sanchez-Cespedes, M. Int. J. Cancer (2006) [Pubmed]
  12. Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. Chim, C.S., Chan, W.W., Pang, A., Kwong, Y.L. Leukemia (2006) [Pubmed]
 
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