The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MAGED1  -  melanoma antigen family D, 1

Homo sapiens

Synonyms: DLXIN-1, MAGE tumor antigen CCF, MAGE-D1 antigen, Melanoma-associated antigen D1, NRAGE, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MAGED1


High impact information on MAGED1

  • It was also found that the majority of cellular Dlxin-1 is retained in the membrane fractions of wild-type but not Ror2-/- mouse embryonic fibroblasts [3].
  • Glutathione S-transferase pull-down and immunoprecipitation/Western blotting assays following co-transfection of Dlxin-1 and Praja1 revealed that Praja1 binds to the C-terminal necdin homology domain of Dlxin-1 in vitro and in vivo, respectively [4].
  • Transfection and reporter gene assays indicate that Dlxin-1 activates the transcriptional function of Dlx5 [5].
  • During embryogenesis, a strong signal for Dlxin-1 mRNA was found in cell layers surrounding cartilaginous elements in bone rudiment during digit formation [5].
  • Therefore, Dlxin-1 may act as a regulator of the function of Dlx family members in bone formation [5].

Biological context of MAGED1


Anatomical context of MAGED1

  • Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult tissues is comparable to that in testis and fetal liver [6].
  • Dlxin-1 mRNA is expressed in various adult tissues, but not the spleen, and also in osteoblastic and chondrogenic cell lines [5].
  • Further studies demonstrated that hNRAGE does not affect the proliferation of mouse p53-/- embryonic fibroblasts, suggesting that p53 function is required for hNRAGE induced cell cycle arrest [8].

Physical interactions of MAGED1


Regulatory relationships of MAGED1


Other interactions of MAGED1


  1. Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion. Xue, B., Wen, C., Shi, Y., Zhao, D., Li, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Tissue distribution of a melanoma-associated antigen D-1 immunogenic in patients with melanoma. Nagai, H., Hayashi, Y., Wang, W., Kako, S., Horikawa, T., Hayashibe, K., Ichihashi, M. J. Dermatol. Sci. (1998) [Pubmed]
  3. The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution. Matsuda, T., Suzuki, H., Oishi, I., Kani, S., Kuroda, Y., Komori, T., Sasaki, A., Watanabe, K., Minami, Y. J. Biol. Chem. (2003) [Pubmed]
  4. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. Sasaki, A., Masuda, Y., Iwai, K., Ikeda, K., Watanabe, K. J. Biol. Chem. (2002) [Pubmed]
  5. Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. Masuda, Y., Sasaki, A., Shibuya, H., Ueno, N., Ikeda, K., Watanabe, K. J. Biol. Chem. (2001) [Pubmed]
  6. Identification of a new, unorthodox member of the MAGE gene family. Põld, M., Zhou, J., Chen, G.L., Hall, J.M., Vescio, R.A., Berenson, J.R. Genomics (1999) [Pubmed]
  7. Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death. Jordan, B.W., Dinev, D., LeMellay, V., Troppmair, J., Gotz, R., Wixler, L., Sendtner, M., Ludwig, S., Rapp, U.R. J. Biol. Chem. (2001) [Pubmed]
  8. hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. Wen, C.J., Xue, B., Qin, W.X., Yu, M., Zhang, M.Y., Zhao, D.H., Gao, X., Gu, J.R., Li, C.J. FEBS Lett. (2004) [Pubmed]
  9. MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. Krämer, B.F., Schoor, O., Krüger, T., Reichle, C., Müller, M., Weinschenk, T., Hennenlotter, J., Stenzl, A., Rammensee, H.G., Stevanovic, S. Cancer Biol. Ther. (2005) [Pubmed]
  10. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Salehi, A.H., Morris, S.J., Ho, W.C., Dickson, K.M., Doucet, G., Milutinovic, S., Durkin, J., Gillard, J.W., Barker, P.A. Chem. Biol. (2006) [Pubmed]
WikiGenes - Universities