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CSNK2A2  -  casein kinase 2, alpha prime polypeptide

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Disease relevance of CSNK2A2

 

High impact information on CSNK2A2

  • The site of this phosphorylation is deleted in nearly all oncogenically activated Myb proteins, resulting in DNA-binding that is independent of CK-II [2].
  • These results strongly suggest that CK II functions primarily in regulating nuclear activities, and that the two catalytic subunits, alpha and alpha', may carry out overlapping functions [1].
  • No major differences were detected in the subcellular distributions of individual CK II subunits, and no evidence was obtained for subunit redistributions during interphase of the cell cycle [1].

References

  1. Casein kinase II is a predominantly nuclear enzyme. Krek, W., Maridor, G., Nigg, E.A. J. Cell Biol. (1992) [Pubmed]
  2. Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Lüscher, B., Christenson, E., Litchfield, D.W., Krebs, E.G., Eisenman, R.N. Nature (1990) [Pubmed]
 
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