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Gene Review

Csnk2a2  -  casein kinase 2, alpha prime polypeptide

Mus musculus

Synonyms: 1110035J23Rik, C77789, CK II alpha', CK2, Casein kinase II subunit alpha'
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Disease relevance of Csnk2a2


High impact information on Csnk2a2

  • Here we show that CK2 regulates PML protein levels by promoting its ubiquitin-mediated degradation dependent on direct phosphorylation at Ser517 [6].
  • Importantly, we found an inverse correlation between CK2 kinase activity and PML protein levels in human lung cancer-derived cell lines and primary specimens [6].
  • The Ck2alpha and Ck2alpha' isoforms (products of the genes Csnk2a1 and Csnk2a2, respectively) are highly homologous, but the reason for their redundancy and evolutionary conservation is unknown [1].
  • The few that survive to populate the epididymis exhibit head abnormalities similar to those described in human globozoospermia, thus Csnk2a2 may be a candidate gene for these inherited syndromes [1].
  • Impairment of AChR cluster formation after replacement of MuSK KI with KIs of other receptor tyrosine kinases correlates with potential CK2-dependent serine phosphorylation within KIs [7].

Chemical compound and disease context of Csnk2a2


Biological context of Csnk2a2

  • The NKX3.1 amino acid sequence includes multiple potential phosphoacceptor sites for protein kinase CK2 [12].
  • We also show that p38 MAPK is able to directly associate with and modulate both casein kinase 2 (CK2) and protein kinase A (PKA), which promote and block APC nuclear import, respectively [13].
  • Protein kinase CK2 is an ubiquitous and pleiotropic Ser/Thr protein kinase composed of two catalytic (alpha and/or alpha') and two noncatalytic (beta) subunits forming a heterotetrameric holoenzyme involved in cell growth and differentiation [14].
  • The kinetics of CK2alpha' expression correlate with increased kinase activity toward a specific CK2 holoenzyme peptide substrate [14].
  • Protein kinase CK2 is a ubiquitous and evolutionarily conserved serine/threonine kinase that is upregulated in many human cancers and can serve as an oncogene in lymphocytes [2].

Anatomical context of Csnk2a2


Associations of Csnk2a2 with chemical compounds


Physical interactions of Csnk2a2


Enzymatic interactions of Csnk2a2


Regulatory relationships of Csnk2a2

  • We demonstrate that p38 MAPK is able to not only enhance CK2 kinase activity but also suppress PKA kinase activity [13].
  • Phosphorylation by CK2 activates the specific DNA binding function of p53 and stimulates its ability to suppress cellular growth [22].

Other interactions of Csnk2a2

  • Genomic DNA was extracted from peripheral blood and PCR was performed to amplify Csnk2a2 and Csnk2b genes before sequencing [23].
  • We report that upon stable transfection of Wnt-1 into the mouse mammary epithelial cell line C57MG, morphological changes and increased proliferation are accompanied by increased levels of CK2, as well as of beta-catenin [24].
  • 5: In addition, DRB (a pharmacological inhibitor of CK2) blocked TNF-alpha release in a concentration-dependent manner, whereas co-treatment of cells with luteolin and DRB did not have an additive effect [25].
  • Experiments are underway to determine whether expression of both CK2 and kinase inactive GSK3 further accelerates tumorigenesis [26].
  • The aim of this study was to determine if CK2 was affected by p53 [20].

Analytical, diagnostic and therapeutic context of Csnk2a2


  1. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Xu, X., Toselli, P.A., Russell, L.D., Seldin, D.C. Nat. Genet. (1999) [Pubmed]
  2. Protein kinase CK2 in mammary gland tumorigenesis. Landesman-Bollag, E., Romieu-Mourez, R., Song, D.H., Sonenshein, G.E., Cardiff, R.D., Seldin, D.C. Oncogene (2001) [Pubmed]
  3. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. Landesman-Bollag, E., Song, D.H., Romieu-Mourez, R., Sussman, D.J., Cardiff, R.D., Sonenshein, G.E., Seldin, D.C. Mol. Cell. Biochem. (2001) [Pubmed]
  4. Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model. Slaton, J.W., Unger, G.M., Sloper, D.T., Davis, A.T., Ahmed, K. Mol. Cancer Res. (2004) [Pubmed]
  5. p53 and the ribosomal protein L5 participate in high molecular mass complex formation with protein kinase CK2 in murine teratocarcinoma cell line F9 after serum stimulation and cisplatin treatment. Guerra, B., Issinger, O.G. FEBS Lett. (1998) [Pubmed]
  6. A CK2-dependent mechanism for degradation of the PML tumor suppressor. Scaglioni, P.P., Yung, T.M., Cai, L.F., Erdjument-Bromage, H., Kaufman, A.J., Singh, B., Teruya-Feldstein, J., Tempst, P., Pandolfi, P.P. Cell (2006) [Pubmed]
  7. Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Cheusova, T., Khan, M.A., Schubert, S.W., Gavin, A.C., Buchou, T., Jacob, G., Sticht, H., Allende, J., Boldyreff, B., Brenner, H.R., Hashemolhosseini, S. Genes Dev. (2006) [Pubmed]
  8. A potential role of nuclear matrix-associated protein kinase CK2 in protection against drug-induced apoptosis in cancer cells. Guo, C., Yu, S., Davis, A.T., Wang, H., Green, J.E., Ahmed, K. J. Biol. Chem. (2001) [Pubmed]
  9. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo. Shore, L.J., Soler, A.P., Gilmour, S.K. J. Biol. Chem. (1997) [Pubmed]
  10. Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization. Ljubimov, A.V., Caballero, S., Aoki, A.M., Pinna, L.A., Grant, M.B., Castellon, R. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  11. Casein kinase ii (protein kinase ck2) regulates serotonin 5-ht(3) receptor channel function in ng108-15 cells. Jones, S., Yakel, J.L. Neuroscience (2003) [Pubmed]
  12. NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells. Li, X., Guan, B., Maghami, S., Bieberich, C.J. Mol. Cell. Biol. (2006) [Pubmed]
  13. Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. Hildesheim, J., Salvador, J.M., Hollander, M.C., Fornace, A.J. J. Biol. Chem. (2005) [Pubmed]
  14. Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. Orlandini, M., Semplici, F., Ferruzzi, R., Meggio, F., Pinna, L.A., Oliviero, S. J. Biol. Chem. (1998) [Pubmed]
  15. Spermatogenesis of mice lacking CK2alpha': failure of germ cell survival and characteristic modifications of the spermatid nucleus. Escalier, D., Silvius, D., Xu, X. Mol. Reprod. Dev. (2003) [Pubmed]
  16. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. Keller, D.M., Lu, H. J. Biol. Chem. (2002) [Pubmed]
  17. Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells(,). Tang, F., Liu, G., He, Z., Ma, W.Y., Bode, A.M., Dong, Z. Mol. Carcinog. (2006) [Pubmed]
  18. Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism. Negulescu, O., Bognar, I., Lei, J., Devarajan, P., Silbiger, S., Neugarten, J. Kidney Int. (2002) [Pubmed]
  19. Determination of mRNA, and protein levels of p53, MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin. Siemer, S., Ornskov, D., Guerra, B., Boldyreff, B., Issinger, O.G. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  20. Tumour suppressor protein p53 released by nuclease digestion increases at the onset of rat liver regeneration. Miró, F., Lelong, J.C., Pancetti, F., Roher, N., Duthu, A., Plana, M., Bourdon, J.C., Bachs, O., May, E., Itarte, E. J. Hepatol. (1999) [Pubmed]
  21. Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. Mead, J.R., Hughes, T.R., Irvine, S.A., Singh, N.N., Ramji, D.P. J. Biol. Chem. (2003) [Pubmed]
  22. A novel system to investigate the phosphorylation of the p53 tumor suppressor protein by the protein kinase CK2. McKendrick, L., Meek, D.W. Cell. Mol. Biol. Res. (1994) [Pubmed]
  23. Search for mutations involved in human globozoospermia. Pirrello, O., Machev, N., Schimdt, F., Terriou, P., Ménézo, Y., Viville, S. Hum. Reprod. (2005) [Pubmed]
  24. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. Song, D.H., Sussman, D.J., Seldin, D.C. J. Biol. Chem. (2000) [Pubmed]
  25. Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Xagorari, A., Roussos, C., Papapetropoulos, A. Br. J. Pharmacol. (2002) [Pubmed]
  26. CK2 as a positive regulator of Wnt signalling and tumourigenesis. Seldin, D.C., Landesman-Bollag, E., Farago, M., Currier, N., Lou, D., Dominguez, I. Mol. Cell. Biochem. (2005) [Pubmed]
  27. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Yang-Feng, T.L., Zheng, K., Kopatz, I., Naiman, T., Canaani, D. Nucleic Acids Res. (1991) [Pubmed]
  28. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Kramerov, A.A., Saghizadeh, M., Pan, H., Kabosova, A., Montenarh, M., Ahmed, K., Penn, J.S., Chan, C.K., Hinton, D.R., Grant, M.B., Ljubimov, A.V. Am. J. Pathol. (2006) [Pubmed]
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