High impact information on granny-smith

• The Drosophila slamdance gene: a mutation in an aminopeptidase can cause seizure, paralysis and neuronal failure [1].
• Using [Leu(5)]enkephalin as a substrate, a captopril sensitive dipeptidyl carboxypeptidase (angiotensin I-converting enzyme) and an amastatin-sensitive aminopeptidase were detected as prominent activities associated with intact discs [2].
• Manduca sexta larvae are highly susceptible to Cry1Ac1, a toxin that is believed to bind M. sexta Aminopeptidase N, a glycoprotein located on the apical membrane [3].
• Cloning of a Heliothis virescens 110 kDa aminopeptidase N and expression in Drosophila S2 cells [4].
• The conversion involves an enzymatic acetylation, and results in an insensitivity to aminopeptidase digestion, suggesting N-terminal blockage [5].

Anatomical context of granny-smith

• Using several convenient peptides as substrates, we have shown that the spermatophore/bursa copulatrix taken from mated female insects possess an aminopeptidase, a carboxypeptidase and a dipeptidase, in addition to high levels of ACE [6].

References