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Gene Review

rag2  -  recombination activating gene 2

Danio rerio

Synonyms: RAG-2, SO:0000704, V(D)J recombination-activating protein 2, rag-2, zgc:136743
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Disease relevance of rag2


High impact information on rag2

  • To follow development of the immune system in zebrafish, we have analyzed the expression of the recombination activating genes, rag1 and rag2, which we have previously isolated and characterized [2].
  • It has been hypothesized that OR gene regulation may involve stochastic DNA rearrangement, which in lymphocytes requires the recombination activating genes, rag1 and rag2 [3].
  • From 1 wpf, rag-1/rag-2 was expressed in kidney (together with immunoglobulin heavy chain expression) but not in spleen, while WCI12+ cells appeared 1 week later in both organs, suggesting B cell recombination in kidney but not in spleen [4].
  • Rag-1/rag-2 expression was detected in thymi of animals over 1-year-old, but in kidney only at low levels, indicating life-long new formation of putative T cells but severely reduced formation of B cells in older fish [4].
  • Rag-1 expression exceeded rag-2 levels in thymus and in head- and trunk-kidney of juveniles, but this ratio was reversed in head- and trunk-kidney from approximately 16 wpf onwards [4].

Biological context of rag2


  1. Myc-induced T cell leukemia in transgenic zebrafish. Langenau, D.M., Traver, D., Ferrando, A.A., Kutok, J.L., Aster, J.C., Kanki, J.P., Lin, S., Prochownik, E., Trede, N.S., Zon, L.I., Look, A.T. Science (2003) [Pubmed]
  2. Expression of zebrafish rag genes during early development identifies the thymus. Willett, C.E., Zapata, A.G., Hopkins, N., Steiner, L.A. Dev. Biol. (1997) [Pubmed]
  3. Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons. Jessen, J.R., Jessen, T.N., Vogel, S.S., Lin, S. Genesis (2001) [Pubmed]
  4. Rag expression identifies B and T cell lymphopoietic tissues during the development of common carp (Cyprinus carpio). Huttenhuis, H.B., Huising, M.O., van der Meulen, T., van Oosterhoud, C.N., Sánchez, N.A., Taverne-Thiele, A.J., Stroband, H.W., Rombout, J.H. Dev. Comp. Immunol. (2005) [Pubmed]
  5. Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish. Willett, C.E., Cherry, J.J., Steiner, L.A. Immunogenetics (1997) [Pubmed]
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