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Gene Review

MFAP4  -  microfibrillar-associated protein 4

Homo sapiens

Synonyms: Microfibril-associated glycoprotein 4
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High impact information on MFAP4


Anatomical context of MFAP4

  • Monoclonal antibodies directed against MFAP4 and SP-A were used for immunohistochemical analysis, which demonstrates that the two molecules colocalize both on the elastic fibres in the interalveolar septum and in elastic lamina of pulmonary arteries of chronically inflamed lung tissue [3].

Associations of MFAP4 with chemical compounds

  • MFAP4 is a collagen-binding molecule containing a C-terminal fibrinogen-like domain and a N-terminal located integrin-binding motif [3].

Analytical, diagnostic and therapeutic context of MFAP4


  1. The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients. Zhao, Z., Lee, C.C., Jiralerspong, S., Juyal, R.C., Lu, F., Baldini, A., Greenberg, F., Caskey, C.T., Patel, P.I. Hum. Mol. Genet. (1995) [Pubmed]
  2. Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D. Lausen, M., Lynch, N., Schlosser, A., Tornoe, I., Saekmose, S.G., Teisner, B., Willis, A.C., Crouch, E., Schwaeble, W., Holmskov, U. J. Biol. Chem. (1999) [Pubmed]
  3. Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung. Schlosser, A., Thomsen, T., Shipley, J.M., Hein, P.W., Brasch, F., Tornøe, I., Nielsen, O., Skjødt, K., Palaniyar, N., Steinhilber, W., McCormack, F.X., Holmskov, U. Scand. J. Immunol. (2006) [Pubmed]
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