Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SCGB2A1 - secretoglobin, family 2A, member 1

Homo sapiens

Synonyms: LIPHC, LPHC, LPNC, Lacryglobin, Lipophilin-C, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SCGB2A1

In the present study, we examined the expression of the mammaglobin genes, MGB1 and MGB2, in the sentinel lymph nodes (SLNs) of patients with breast cancer and compared our results with the histologic status of the same SLNs [1].
Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas [2].
Two control patients with lacryglobin had a family history of breast and prostate cancer [3].
We have identified a novel biomarker, mammaglobin-2 (MGB2), which is highly expressed specific to ovarian cancer [4].

High impact information on SCGB2A1

Lipophilin C mRNA levels did not vary significantly between wild-type and estramustine-resistant cells in prostate (DU145 and PC3) and ovarian (SKOV3) cancer cell lines [5].
RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes [1].
Mammaglobin 2, kallikreins 6, 7, 8, 10, 11, claudin 3 and 4 and B7-H4 gene expression products represent candidate biomarkers endowed with great potential for early screening and therapy of OSPC patients [6].
Mammaglobin 2, an ovarian secreted protein, was identified as the top differentially expressed gene in OSPC (19 out 19 OSPC versus 0 out of 15 HOSE) with over 827-fold up-regulation relative to HOSE [6].
Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%) [3].

Biological context of SCGB2A1

The gene for lipophilin C (also called mammaglobin b) is located on chromosome 11q12-q13.1, near the mammaglobin gene, a homologue overexpressed in many breast cancers [7].

Anatomical context of SCGB2A1

Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells [8].

Other interactions of SCGB2A1

Lipophilins B and C (SCGB2A1, mammaglobin B) were the most prominently expressed secretoglobin mRNAs in the pituitary [9].

References

RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. Ouellette, R.J., Richard, D., Maïcas, E. Am. J. Clin. Pathol. (2004) [Pubmed]
Lipophilin, a novel heterodimeric protein of human tears. Lehrer, R.I., Xu, G., Abduragimov, A., Dinh, N.N., Qu, X.D., Martin, D., Glasgow, B.J. FEBS Lett. (1998) [Pubmed]
Lacryglobin in human tears, a potential marker for cancer. Evans, V., Vockler, C., Friedlander, M., Walsh, B., Willcox, M.D. Clin. Experiment. Ophthalmol. (2001) [Pubmed]
Predicting biomarkers for ovarian cancer using gene-expression microarrays. Adib, T.R., Henderson, S., Perrett, C., Hewitt, D., Bourmpoulia, D., Ledermann, J., Boshoff, C. Br. J. Cancer (2004) [Pubmed]
Evaluation of lipophilins as determinants of tumor cell response to estramustine. Tucker, J.M., Lipatova, Z., Beljanski, V., Townsend, D.M., Tew, K.D. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas: Identification of novel molecular biomarkers for early diagnosis and therapy. Bignotti, E., Tassi, R.A., Calza, S., Ravaggi, A., Romani, C., Rossi, E., Falchetti, M., Odicino, F.E., Pecorelli, S., Santin, A.D. Gynecol. Oncol. (2006) [Pubmed]
Lipophilins: human peptides homologous to rat prostatein. Zhao, C., Nguyen, T., Yusifov, T., Glasgow, B.J., Lehrer, R.I. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
Identification of mammaglobin B, a novel member of the uteroglobin gene family. Becker, R.M., Darrow, C., Zimonjic, D.B., Popescu, N.C., Watson, M.A., Fleming, T.P. Genomics (1998) [Pubmed]
Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas. Sjödin, A., Guo, D., Lund-Johansen, M., Krossnes, B.K., Lilleng, P., Henriksson, R., Hedman, H. Acta Neuropathol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

LOC722315	Macaca mulatta
SCGB2A1	Pan troglodytes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.