Gene Review:
LHX8 - LIM homeobox 8
Gallus gallus
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High impact information on LHX8
- In contrast, no expression of L3/Lhx8 was detected in the epithelium-free mesenchyme [1].
- The maxillary mesenchyme with epithelium showed significant levels of L3/Lhx8 gene expression [1].
- Expression and regulation of the LIM homeodomain gene L3/Lhx8 suggests a role in upper lip development of the chick embryo [1].
- Our data suggest that the L3/Lhx8 gene contributes to epithelial mesenchymal interaction in facial morphogenesis and that Fgf-8b and TGF-beta3 were, at least in part, responsible for the Lhx expression in the maxillary process [1].
- To determine whether the expression of L3/Lhx8 in the maxillary primordia required signals from the overlying oral epithelium, maxillary processes of stage 23 HH chick embryos were transplanted into the limb bud, in which the mesenchyme was grown in the presence or absence of oral epithelium [1].
Analytical, diagnostic and therapeutic context of LHX8
- Whole-mount in situ hybridization showed that L3/Lhx8 mRNA was expressed from stage 15--31 HH in overlapping domains of the maxillary process [1].
References
- Expression and regulation of the LIM homeodomain gene L3/Lhx8 suggests a role in upper lip development of the chick embryo. Inoue, M., Kawakami, M., Tatsumi, K., Manabe, T., Makinodan, M., Matsuyoshi, H., Kirita, T., Wanaka, A. Anat. Embryol. (2006) [Pubmed]
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