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Gene Review

SNF4Agamma  -  SNF4/AMP-activated protein kinase gamma...

Drosophila melanogaster

Synonyms: 0050/42, 0127/19, AMPK&ggr, AMPKgamma, AMPgamma, ...
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Psychiatry related information on SNF4Agamma


High impact information on SNF4Agamma

  • The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing [1].
  • The loe phenotype is modified by the level of HMG-CoA reductase and suppressed by the inhibition of this enzyme by statin, which has been used for the treatment of Alzheimer patients [1].
  • Phylogenetic analysis of yeast, invertebrate, and multiple mammalian isoforms of SNF4 shows that the gene duplication likely occurred early in the metazoan lineage, as the protein products of the different loci are relatively divergent [2].
  • When the phylogeny was extended beyond the SNF4 gene family, SNF4 shares sequence similarity with other cystathionine-beta-synthase domain-containing proteins, including IMP dehydrogenase and a variety of uncharacterized Methanococcus proteins [2].
  • Southern analysis of Drosophila genomic DNA in concert with a survey of mammalian SNF4 ESTs indicates that in metazoans, SNF4 is a duplicated gene, and possibly even a larger gene family [2].


  1. The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. Tschäpe, J.A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G., Kretzschmar, D. EMBO J. (2002) [Pubmed]
  2. Sequence and phylogenetic analysis of the SNF4/AMPK gamma subunit gene from Drosophila melanogaster. Yoshida, E.N., Benkel, B.F., Fong, Y., Hickey, D.A. Genome (1999) [Pubmed]
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