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Gene Review

Hmgcr  -  HMG Coenzyme A reductase

Drosophila melanogaster

Synonyms: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, BcDNA:LD15354, CG10367, Clb, DmHMG-CoAr, ...
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Disease relevance of Hmgcr


Psychiatry related information on Hmgcr


High impact information on Hmgcr


Biological context of Hmgcr


Anatomical context of Hmgcr

  • These findings suggest that Hmgcr might orchestrate germ cell migration by promoting the release and/or transport of Hh from the SGPs [7].

Associations of Hmgcr with chemical compounds


Other interactions of Hmgcr


Analytical, diagnostic and therapeutic context of Hmgcr


  1. Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica. Martinez-Gonzalez, J., Buesa, C., Piulachs, M.D., Belles, X., Hegardt, F.G. Eur. J. Biochem. (1993) [Pubmed]
  2. Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila. Belgacem, Y.H., Martin, J.R. PLoS ONE (2007) [Pubmed]
  3. The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. Tschäpe, J.A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G., Kretzschmar, D. EMBO J. (2002) [Pubmed]
  4. Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase. Gertler, F.B., Chiu, C.Y., Richter-Mann, L., Chin, D.J. Mol. Cell. Biol. (1988) [Pubmed]
  5. Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Stein, J.A., Broihier, H.T., Moore, L.A., Lehmann, R. Development (2002) [Pubmed]
  6. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Thorpe, J.L., Doitsidou, M., Ho, S.Y., Raz, E., Farber, S.A. Dev. Cell (2004) [Pubmed]
  7. HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. Deshpande, G., Schedl, P. Dev. Cell (2005) [Pubmed]
  8. Isopentenoid synthesis in isolated embryonic Drosophila cells. Possible regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by shunted mevalonate carbon. Havel, C., Rector, E.R., Watson, J.A. J. Biol. Chem. (1986) [Pubmed]
  9. Isoprenoid synthesis in isolated embryonic Drosophila cells. Sterol-independent regulatory signal molecule is distal to isopentenyl 1-pyrophosphates. Watson, J.A., Havel, C.M., Lobos, D.V., Baker, F.C., Morrow, C.J. J. Biol. Chem. (1985) [Pubmed]
  10. Isoprene synthesis in isolated embryonic Drosophila cells. II. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Brown, K., Havel, C.M., Watson, J.A. J. Biol. Chem. (1983) [Pubmed]
  11. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos, A.C., Lehmann, R. Dev. Cell (2004) [Pubmed]
  12. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Yi, P., Han, Z., Li, X., Olson, E.N. Science (2006) [Pubmed]
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