The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rfabg  -  Retinoid- and fatty acid-binding glycoprotein

Drosophila melanogaster

Synonyms: ApoL1, ApoL2, ApoLI, ApoLII, Apolipophorins, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on RfaBp

  • We now demonstrate that ultraspiracle (usp), a Drosophila RXR homolog, can substitute for RXR in stimulating the DNA binding of receptors for retinoic acid, T3, vitamin D, and peroxisome proliferator activators [1].
  • The nuclear receptors for 1,25-dihydroxyvitamin D3 (VD) and 3,5,3'-triiodothyronine (T3), that is, VDRs and T3Rs respectively, control aspects of homeostasis, cell growth and differentiation [2].
  • The gene, localized to the chromosome 4 (102 F region), encodes a 3351-amino acid protein that could serve as the precursor for the approximately 70-kDa and >200-kDa polypeptides associated with RFABG [3].
  • To determine whether the weak response of the rat CaBP9k natural promoter to 1,25-(OH)2D3 could be enhanced by T3, CaBP9k promoter/reporter chloramphenicol acetyltransferase constructs were transfected in MCF-7 cells, and the cells were treated with the two hormones alone or in combination [4].
  • Heme added to a solution of purified RFABG bound in a saturable manner with an affinity of 3.8 x 10(-7) m.Thus, the current study clearly demonstrates that retinoid- and fatty acid-binding glycoprotein is a novel heme-binding protein, which may be involved in the transport and/or metabolism of heme in Drosophila [5].

Biological context of RfaBp


Associations of RfaBp with chemical compounds


Analytical, diagnostic and therapeutic context of RfaBp


  1. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Yao, T.P., Segraves, W.A., Oro, A.E., McKeown, M., Evans, R.M. Cell (1992) [Pubmed]
  2. Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation. Schräder, M., Müller, K.M., Nayeri, S., Kahlen, J.P., Carlberg, C. Nature (1994) [Pubmed]
  3. Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin. Kutty, R.K., Kutty, G., Kambadur, R., Duncan, T., Koonin, E.V., Rodriguez, I.R., Odenwald, W.F., Wiggert, B. J. Biol. Chem. (1996) [Pubmed]
  4. Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation. Raval-Pandya, M., Freedman, L.P., Li, H., Christakos, S. Mol. Endocrinol. (1998) [Pubmed]
  5. Heme-binding by Drosophila retinoid- and fatty acid-binding glycoprotein (RFABG), a member of the proapolipophorin gene family. Duncan, T., Osawa, Y., Kutty, R.K., Kutty, G., Wiggert, B. J. Lipid Res. (1999) [Pubmed]
  6. Molecular characterization and gene expression in the eye of the apolipophorin II/I precursor from Locusta migratoria. Bogerd, J., Babin, P.J., Kooiman, F.P., André, M., Ballagny, C., van Marrewijk, W.J., van der Horst, D.J. J. Comp. Neurol. (2000) [Pubmed]
  7. RXR-independent action of the receptors for thyroid hormone, retinoid acid and vitamin D on inverted palindromes. Carlberg, C. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
WikiGenes - Universities