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Gene Review:

IGFBP-6 - insulin-like growth factor binding protein 6

Ovis aries

Gadd, T.S. et al., de los Rios, P. et al., Osgerby, J.C. et al., De Los Rios, P. et al.

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High impact information on IGFBP-6

Messenger RNAs encoding each species were identified by Northern blot analysis within chondrocytes, as was mRNA encoding IGFBP-6 [1].
In most regions IGFBP-6 mRNA showed cyclic variations with concentrations maximal around ovulation and the early luteal phase [2].
In conclusion, IGFBP-6 mRNA is differentially regulated during the estrous cycle and pregnancy and may be functionally important in modulating IGF activity in the uterus and placenta by virtue of its strong affinity and ability to regulate IGF-II mediated actions [2].
In addition, 16 out of 25 ewes expressed IGFBP-6 mRNA in their endometrial glands between estrus and Day 2 [2].
In nonpregnant ewes IGFBP-6 mRNA (measured as arbitrary optical density units from autoradiographs) was abundant in the periepithelium and caruncles, with lower levels in the endometrial stroma and myometrium [2].

Biological context of IGFBP-6

Because the anatomical distribution of IGFBPs is likely to dictate IGF bioavailability, we determined the cellular distribution and expression of IGF-I, IGF-II, and IGFBP-1 to IGFBP-6 in epiphyseal growth plates of the fetal sheep, using immunocytochemistry and in situ hybridization [3].

Anatomical context of IGFBP-6

These changes were accompanied by higher IGFBP-6 mRNA expression in the maternal placental villi in undernourished ewes (P<0.05) [4].

References

Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus. De Los Rios, P., Hill, D.J. J. Cell. Physiol. (2000) [Pubmed]
Regulation of insulin-like growth factor binding protein-6 expression in the reproductive tract throughout the estrous cycle and during the development of the placenta in the ewe. Gadd, T.S., Osgerby, J.C., Wathes, D.C. Biol. Reprod. (2002) [Pubmed]
Cellular localization and expression of insulin-like growth factors (IGFs) and IGF binding proteins within the epiphyseal growth plate of the ovine fetus: possible functional implications. de los Rios, P., Hill, D.J. Can. J. Physiol. Pharmacol. (1999) [Pubmed]
The effect of maternal undernutrition on the placental growth trajectory and the uterine insulin-like growth factor axis in the pregnant ewe. Osgerby, J.C., Wathes, D.C., Howard, D., Gadd, T.S. J. Endocrinol. (2004) [Pubmed]

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