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Gene Review

ITGAM  -  integrin, alpha M (complement component 3...

Ovis aries

Synonyms: C3bi, CD11B, CR3
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High impact information on ITGAM

  • Therefore, different signal transducing mechanisms for phagocytosis appear to be triggered by the binding of Hc yeasts to CD18, and by the binding of EC3bi to CD11b/CD18, respectively [1].
  • In the presence of bound Mn2+, the three- dimensional structure of the ligand-binding A-domain from the integrin CR3 (CD11b/CD18) is shown to exist in the "open" conformation previously described only for a crystalline Mg2+ complex [2].
  • The binding activity of CD11b/CD18 was also enhanced 3- to 10-fold by these peptides, but enhanced function was transient: binding of erythrocytes coated with C3bi reached a maximum by 30 min and declined thereafter [3].
  • CD11b/CD18 is a heterodimeric leukocyte surface receptor which functions in both C3bi-ligand binding and homotypic and heterotypic cell adherence [4].
  • Phenotypic analysis by flow cytometry and immunohistochemical techniques of the inflammatory cells responding to F1 fraction showed a prevalence of (CD11b/CD18, Mac-1)+ peritoneal macrophages [5].

Biological context of ITGAM

  • In turn, acylation of Lys860 alone did not permit toxin activity on erythrocytes, while it fully supported the high-affinity binding of CyaA-K983R to the toxin receptor CD11b/CD18 and conferred on CyaA-K983R a reduced but substantial capacity to penetrate and kill the CD11b+ cells [6].

Anatomical context of ITGAM

  • An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors [4].
  • These results suggest that inflammatory (CD11b/CD18)+ macrophages may be related to immunological disturbances, caused by cell wall components of P. brasiliensis [5].

Associations of ITGAM with chemical compounds


  1. Phagocytosis of Histoplasma capsulatum yeasts and microconidia by human cultured macrophages and alveolar macrophages. Cellular cytoskeleton requirement for attachment and ingestion. Newman, S.L., Bucher, C., Rhodes, J., Bullock, W.E. J. Clin. Invest. (1990) [Pubmed]
  2. Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. Li, R., Rieu, P., Griffith, D.L., Scott, D., Arnaout, M.A. J. Cell Biol. (1998) [Pubmed]
  3. Differential effects of neutrophil-activating peptide 1/IL-8 and its homologues on leukocyte adhesion and phagocytosis. Detmers, P.A., Powell, D.E., Walz, A., Clark-Lewis, I., Baggiolini, M., Cohn, Z.A. J. Immunol. (1991) [Pubmed]
  4. An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors. Graham, I.L., Gresham, H.D., Brown, E.J. J. Immunol. (1989) [Pubmed]
  5. Cellular requirements for immunomodulatory effects caused by cell wall components of Paracoccidioides brasiliensis on antibody production. Silva, M.F., Bocca, A.L., Ferracini, R., Figueiredo, F., Silva, C.L. Clin. Exp. Immunol. (1997) [Pubmed]
  6. Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Masin, J., Basler, M., Knapp, O., El-Azami-El-Idrissi, M., Maier, E., Konopasek, I., Benz, R., Leclerc, C., Sebo, P. Biochemistry (2005) [Pubmed]
  7. Staurosporine inhibits neutrophil phagocytosis but not iC3b binding mediated by CR3 (CD11b/CD18). Roubey, R.A., Ross, G.D., Merrill, J.T., Walton, F., Reed, W., Winchester, R.J., Buyon, J.P. J. Immunol. (1991) [Pubmed]
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